ID G3PA17_GASAC Unreviewed; 968 AA.
AC G3PA17;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL1A {ECO:0000313|Ensembl:ENSGACP00000014441.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000014441.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000014441.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000014441.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3PA17; -.
DR STRING; 69293.ENSGACP00000014441; -.
DR Ensembl; ENSGACT00000014467.1; ENSGACP00000014441.1; ENSGACG00000010903.1.
DR eggNOG; KOG2209; Eukaryota.
DR GeneTree; ENSGT00940000155295; -.
DR InParanoid; G3PA17; -.
DR OMA; AQTCQQK; -.
DR TreeFam; TF320922; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000010903; Expressed in spleen and 11 other cell types or tissues.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13285; PH_ORP1; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF53; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT REPEAT 50..82
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 83..115
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 185..217
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 247..347
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 352..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 897..931
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 968 AA; 108865 MW; 1FBE3E8E00152FC6 CRC64;
SMEEPEEQFL QFARNGDLPG LQRLLLSTMR EETHININCR GTAGKRKSNL GWTPLHLASY
FGHKDVVEEL LKVGADVNLP NNVGDTALHK AAFTGRKEVV MLLLHYGACA AVINGTAQIP
KDVTQSAEIR GMLEDHFAKK QAAQRTEERK QEEELLEAAR EGDLSTLTRL LSRKKSPDIN
CTDLLGNTPL HSAAYRGQRP CVLKLLRGGA SANVENNKGQ TALDLASSAA IKLVLEGTAH
RGGTRHVKKH QGLLWKSSRF FGWRSYWVVL QDGVMSWYSK QSDAASNVSR QGCKSLTRSQ
CLVRDKDSCF FTLKCFDDSL HHFKVSPKSD PEATAKAWLQ AVEEHSAYST HYCSQEQGSE
EEEHEEEAKS LGELTESLQA AEAHQEELEE EVEALVSMLR DGGLAESFPS TVTQKLQEIR
VLSGETSACL RVCLGLLSRQ EVVRSLRLEQ QVEKNRILSE ALQTLATEHH QLEQSVVGGP
PPPSEDEFHD AVSGSSWGRS LAHTLVLLCA RLHHLASWHQ SIGYISYRTI RLKSAGGGQR
RSRLLNIDRS RTSLPAPMFS RNDFSIWSIL RNCIGMELSK ITMPVIFNEP LSFLQRLTEY
MEHTYLLQRA NACPDSTQRM KCVAAFAVSA VASQWERTGK PFNPLLGETY ELLPREDLGF
RLLSEQVSHH PPVSAFHAEG LQQDFVFHGS IYPKLKFWGK SVEAEPKGLI TLELPKHNEA
YTWTNPTCCV HNIIVGQLWI EQYGTMELLN HRTGEKCCLN FKPCGLFGKE LHKVEGHILD
KSRKKLCALY GKWTECLYAV EPAAFEAHKK SDKKATAQKK GGKAVGSSGA LEEVPSPAAD
TVEMIPGSQL LWRIAPRPAN STQMYSFTSF AMQLNELHTE MEASLPRTDC RLRPDIRAME
NGDIDVASEE KKRLEEKQRA TRKDRSKCDE EWKTRWFQQG PNPHTDSQDW LFCSAYWDRK
YSQLPDIY
//
