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Database: UniProt
Entry: G3PA82_GASAC
LinkDB: G3PA82_GASAC
Original site: G3PA82_GASAC 
ID   G3PA82_GASAC            Unreviewed;       514 AA.
AC   G3PA82;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=O-acyltransferase {ECO:0000256|PIRNR:PIRNR000439};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000014506.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000014506.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000014506.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-
CC         octadecenoate + CoA; Xref=Rhea:RHEA:64324, ChEBI:CHEBI:16113,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:75121, ChEBI:CHEBI:88768;
CC         Evidence={ECO:0000256|ARBA:ARBA00036418};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64325;
CC         Evidence={ECO:0000256|ARBA:ARBA00036418};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(7Z)-octadecenoyl-CoA + cholesterol = cholesteryl (7Z)-
CC         octadecenoate + CoA; Xref=Rhea:RHEA:64328, ChEBI:CHEBI:16113,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:152049, ChEBI:CHEBI:152050;
CC         Evidence={ECO:0000256|ARBA:ARBA00036957};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64329;
CC         Evidence={ECO:0000256|ARBA:ARBA00036957};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-
CC         hexadecenoate + CoA; Xref=Rhea:RHEA:64320, ChEBI:CHEBI:16113,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:61540, ChEBI:CHEBI:84323;
CC         Evidence={ECO:0000256|ARBA:ARBA00037015};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64321;
CC         Evidence={ECO:0000256|ARBA:ARBA00037015};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(9Z,12Z)-octadecadienoyl-CoA + cholesterol = cholesteryl
CC         (9Z,12Z)-octadecadienoate + CoA; Xref=Rhea:RHEA:42796,
CC         ChEBI:CHEBI:16113, ChEBI:CHEBI:41509, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57383; Evidence={ECO:0000256|ARBA:ARBA00036867};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42797;
CC         Evidence={ECO:0000256|ARBA:ARBA00036867};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesterol + hexadecanoyl-CoA = cholesteryl hexadecanoate +
CC         CoA; Xref=Rhea:RHEA:42792, ChEBI:CHEBI:3663, ChEBI:CHEBI:16113,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379;
CC         Evidence={ECO:0000256|ARBA:ARBA00036161};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42793;
CC         Evidence={ECO:0000256|ARBA:ARBA00036161};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesterol + octadecanoyl-CoA = cholesteryl octadecanoate +
CC         CoA; Xref=Rhea:RHEA:42812, ChEBI:CHEBI:16113, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57394, ChEBI:CHEBI:82750;
CC         Evidence={ECO:0000256|ARBA:ARBA00036931};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42813;
CC         Evidence={ECO:0000256|ARBA:ARBA00036931};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|PIRNR:PIRNR000439}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|PIRNR:PIRNR000439}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
CC       Sterol o-acyltransferase subfamily. {ECO:0000256|ARBA:ARBA00009010,
CC       ECO:0000256|PIRNR:PIRNR000439}.
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DR   AlphaFoldDB; G3PA82; -.
DR   Ensembl; ENSGACT00000014532.1; ENSGACP00000014506.1; ENSGACG00000010924.1.
DR   GeneTree; ENSGT00950000183081; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000010924; Expressed in mesonephros and 1 other cell type or tissue.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008374; F:O-acyltransferase activity; IEA:InterPro.
DR   InterPro; IPR004299; MBOAT_fam.
DR   InterPro; IPR014371; Oat_ACAT_DAG_ARE.
DR   PANTHER; PTHR10408; STEROL O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR10408:SF6; STEROL O-ACYLTRANSFERASE 1; 1.
DR   Pfam; PF03062; MBOAT; 1.
DR   PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|PIRNR:PIRNR000439};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|PIRNR:PIRNR000439};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR000439};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000439};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        101..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        142..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        179..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        326..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        434..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        465..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        424
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000439-1"
SQ   SEQUENCE   514 AA;  60486 MW;  FE90867A5C98FC1D CRC64;
     GKIEVEQVIS KKLQLKRKAE FLKTDLMHQL GSQVNDFMDS LIEESAILEP APVPAVFSPP
     LSDKERGKLR NFRPPHGEGK HFVSRRSLLD ELLEVNHIRT IYHMFIALLI LLILSTLVVD
     FIDEGRPVLH FDLLVYAFGQ FPLVLCTWIC MFLSVLLVPY SLFHLWVQTQ CGSSSHPGLC
     SLLFGSVFLL YQAVGVGFLP TYVVVTNSLP PASCFIIILE QVRLMMKAHS FVRENVPRVL
     TWAEEKTTLD PRPEFPQVSQ YIYFLFAPTL IYRDKYPRNP VIRWSYVATK FLQVLGCMFY
     VYYVFVRLCI PQFRSISLQL FDRRAMVLCV FNSILPGVLI LFLGFFSFLH CWLNAFGEML
     QFADRMFYKD WWNSTSFANY YRTWNVVVHN WLYYYVYRDF LWLSRKRFRP VAMLFVFTLS
     AVVHEYILAI CFGFFYPVLF CLFMCFGMMF NFILHDQRKG PIWNIIMWTS LFLGQGVIIC
     LYSQEWYARH YCPLKEPSLL ELLKPRSWSC QRAF
//
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