ID G3PAL9_GASAC Unreviewed; 1231 AA.
AC G3PAL9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000014643.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000014643.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000014643.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR AlphaFoldDB; G3PAL9; -.
DR STRING; 69293.ENSGACP00000014643; -.
DR Ensembl; ENSGACT00000014669.1; ENSGACP00000014643.1; ENSGACG00000011062.1.
DR eggNOG; KOG0791; Eukaryota.
DR GeneTree; ENSGT00940000156870; -.
DR InParanoid; G3PAL9; -.
DR OMA; ASNYTYR; -.
DR TreeFam; TF351926; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000011062; Expressed in spleen and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 7.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF5; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 8.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 875..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..110
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 112..200
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 201..287
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 288..373
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 374..460
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 461..554
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 633..721
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 947..1204
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1122..1195
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 99..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1231 AA; 136640 MW; BF84078B2573A760 CRC64;
LIPGTRYTIS VIAVAGDNQK KSSSCVHCAH TEPEVVRNIT VTNVTTSSIS LTWNDPKGNS
SSYRVQWTDS VDTTSITITN LTAGVQYKIT VAAVTNEGST EGQNTSVSQY TRPGEIGTPT
VSTNTSSISL NWTSPPGEVF KFRLEWSSNG DMRNMCTYDN FAVISELIPG TSYTISVIAI
AGDNQTEGRA HRITAVTKPE VVRNITVANV TTSSISLKWI EPKGNSSFYR VQWTDGNVTH
NNSVNTTSIT ITNLTAGVQY KITVAAVTNE GSTEGQNTSV SQYTRPGEIG TPTVSTNTSS
ISLNWTSPPG EVFKFRLEWS SNGAIRNMCT YDNFAVISEL IPGTSYTISV IAVAGDNQTE
GRAHRVTAVT KPEVVRNITV ANVTTSSISL KWIEPKGNSS SYRVQWTDGN VTHNNSVNTT
SVTITNLTAG VQYKITVAAV TNEGNTEGQN TSVYQYTRPG EIGTPTVSTN TSSISLNWTS
PPGEVFKFRL EWSSNGDMRN MCTYDNFAVI SELIPGTSYT ISVIAVAGDN QTEGRAHPSP
QSQPKAVADL TVEEQNTTSV RLTWLRRGQC MQSYTKRLKV SDESIRNTPI TRFYSKINDL
VPGKQYNISV TTETVDGTEG APIWISVCTN AGAVKDLICD GPDTTIAQVI LSWKKNNGQN
SGFKVTVNNG ETVNYTHSCC NYTVSNLRHN TSYNLSVETQ SCGLPSRPET RLCWTGITNP
PIPKNYQDLV VVTNKEYNKF SLQIKRGLLD SINGPITHVG VLVTQTDPGA SDLTTYVSKT
YQEWKEQATQ VYMATVKNLT ETTVTSRSEE GPLDIEIGSE NKWGAYFNGP LEANEKYQYA
IVLFTRLTLD NQLVTGKLLA ATKFYNFVQL PQNPVVISIA IGVTLGIFCV LLIILIGFII
YWKSLTQNES HEPALTSGFH LSRSVAVRVE EFEAYYKKQK ADSSCGFAEE FEDMKLVGTA
QSKTQALTLE NKPKNRYNNV LPYDSSRVKL SIIHGSPYED YINANYMPGY NSRKEYIAAQ
GPLPATVNEF WRMIWEKNVQ TLVMLTRCNE QGRVKCEQYW DHGTKHFDKI TVTTSSEIEL
EDWTIRDFYV KNVKTAETRL VRHFHFTAWP DHGVPQTTEL LISFRHLVRE HMDQYSRNSP
TVVHCSAGVG RTGTFITIDR LIFQIERENL VDVYGIVHDL RMHRPLMVQT EDQYVFLNQC
ALDIIRSRTG NNVDLIYQNS AAMSIYENID P
//
