ID G3PAY9_GASAC Unreviewed; 224 AA.
AC G3PAY9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=DNA replication complex GINS protein SLD5 {ECO:0000256|ARBA:ARBA00014804, ECO:0000256|PIRNR:PIRNR007764};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000014763.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000014763.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000014763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for initiation of chromosomal DNA replication. Core
CC component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that
CC unwinds template DNA during replication, and around which the replisome
CC is built. {ECO:0000256|PIRNR:PIRNR007764}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR007764}.
CC -!- SIMILARITY: Belongs to the GINS4/SLD5 family.
CC {ECO:0000256|ARBA:ARBA00008187, ECO:0000256|PIRNR:PIRNR007764}.
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DR AlphaFoldDB; G3PAY9; -.
DR Ensembl; ENSGACT00000014791.1; ENSGACP00000014763.1; ENSGACG00000011159.1.
DR GeneTree; ENSGT00390000003246; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000011159; Expressed in head kidney and 8 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd11711; GINS_A_Sld5; 1.
DR CDD; cd21692; GINS_B_Sld5; 1.
DR Gene3D; 1.20.58.1030; -; 1.
DR Gene3D; 3.40.5.60; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR008591; GINS_Sld5.
DR InterPro; IPR031633; SLD5_C.
DR InterPro; IPR038749; Sld5_GINS_A.
DR PANTHER; PTHR21206:SF0; DNA REPLICATION COMPLEX GINS PROTEIN SLD5; 1.
DR PANTHER; PTHR21206; SLD5 PROTEIN; 1.
DR Pfam; PF05916; Sld5; 1.
DR Pfam; PF16922; SLD5_C; 1.
DR PIRSF; PIRSF007764; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
DR SUPFAM; SSF160059; PriA/YqbF domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR007764};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007764};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 51..127
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
FT DOMAIN 166..224
FT /note="DNA replication complex GINS protein SLD5 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16922"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 45..72
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 224 AA; 25792 MW; BC422AFC11C7ED51 CRC64;
MSDALSDDGS DVHQDETQEE VMTPAELIGK LEEAWLNEKF SPELLENKSE VVECAMEQLS
HMEENLQRVK KGDMKASVHR MEIDRIRFVL SSYLRARLQK IEKFFPHVLE REKSRGEGDP
SLLSPEEFAF AKEYYANTET YLKAIALKRM PPNLQAVDML KAVPEPCLDS FVFLRVKERQ
ENIMVEPESD DQREYVVDLE EGSQHLMRYR AVAPLVSSGA VQLI
//
