ID G3PBW9_GASAC Unreviewed; 834 AA.
AC G3PBW9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Endothelial PAS domain protein 1b {ECO:0000313|Ensembl:ENSGACP00000015093.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000015093.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000015093.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000015093.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3PBW9; -.
DR STRING; 69293.ENSGACP00000015093; -.
DR Ensembl; ENSGACT00000015121.1; ENSGACP00000015093.1; ENSGACG00000011414.1.
DR eggNOG; KOG3558; Eukaryota.
DR GeneTree; ENSGT00940000155930; -.
DR InParanoid; G3PBW9; -.
DR OMA; KTEPDHR; -.
DR TreeFam; TF317772; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000011414; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:Ensembl.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:1990402; P:embryonic liver development; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0043523; P:regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0014823; P:response to activity; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23043:SF8; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 13..65
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 88..158
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 253..302
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..436
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 90436 MW; 570B581ADC03AC53 CRC64;
LCPTVPRRRS SSERRKEKSR DARSRRSKET EVFYELAHQL PLPRQAPHLD KASIMRLAIS
FLRTRKVIAT GKSACSGRGS SGRDGEDDQQ MDSLYLKSLE GFVTMVTSDG DMIFLSENIS
KFMGLTQVDL TGHSIFDFTH PCDHEEIREN LSLKSSGSGK KGKDLSTERD FFMRMKCTVT
NRGRTVNLKS ASWKVLHCTG HLKMYSSCPP RVLCGFSEPP LTCAVLMCEP VAHPSNIDAP
LDSKTFLSRH GMDMKFTYCD ESVTQLMGYA PEDLLGRSAY DFYHALDSDG VTKSHHNLCS
KGQAVSGQYR MLAKNGGYVW VETQGTVIYN SRNSQPQCIV CINYVLSDIE EKSMVLSLKQ
TESMFKPQGM SSFFTAGDAG AAGEPGDALF AKLKEEPEEL TQLAPTPGDT IVSLDFDRPP
FEEPPPPPPV GYPQVPPAAA SLPGTASWVS EISRPGPPAS AQRDAANAFT VPQNPPPGSA
TPSLSSCSTP SSPGDYYSPV ESDLKVELTE KLFSLDTDES TPANTECDLS DLDLETLAPY
IPMDGEDFQL HPIVPEAEAL EAGPAGSGGP AVGLAAAQQP TQRSFSNIAS LFQPLASPPQ
PRGLYREQPA APWAAGEKGC SGQGAVDSGP GSCLLGHLQN VPAAASTPLS SMGGRQNLLW
PPDPLITYQQ QLQASKAYLM QPFPGEQRPS CQQNMPHLMQ KHSRSIDNFV QAYRDMSPAN
VAVANSIKRS FTQMAVGDGT PSENIWKKMR RDSSAGSLAA SEMGRMTPGG VSPFLSSAQQ
HRKCQYPGNG TGGDDEKLFL RKSCSYTYNT QPCNKTEGMV SRLLGPSFES SCLP
//
