ID G3PEY0_GASAC Unreviewed; 783 AA.
AC G3PEY0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) {ECO:0000313|Ensembl:ENSGACP00000016154.1};
GN Name=H6PD {ECO:0000313|Ensembl:ENSGACP00000016154.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000016154.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000016154.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000016154.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway.
CC {ECO:0000256|ARBA:ARBA00004959}.
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DR AlphaFoldDB; G3PEY0; -.
DR STRING; 69293.ENSGACP00000016154; -.
DR Ensembl; ENSGACT00000016185.1; ENSGACP00000016154.1; ENSGACG00000012197.1.
DR eggNOG; KOG0563; Eukaryota.
DR eggNOG; KOG3147; Eukaryota.
DR GeneTree; ENSGT00530000063435; -.
DR InParanoid; G3PEY0; -.
DR OMA; YCPQSGT; -.
DR TreeFam; TF354247; -.
DR UniPathway; UPA00115; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000012197; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:InterPro.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR CDD; cd01400; 6PGL; 1.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR019796; G6P_DH_AS.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01198; pgl; 1.
DR PANTHER; PTHR23429:SF7; GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 26..208
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 214..497
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT DOMAIN 552..774
FT /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT /evidence="ECO:0000259|Pfam:PF01182"
FT BINDING 205
FT /ligand="substrate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10005"
SQ SEQUENCE 783 AA; 88031 MW; 2AA8D7B81E4BF74C CRC64;
WTLAALCQQW RGCMAGAPRS GHVSVVIVGG TGDLAKKYLW QGFFELYVHQ VGSGNTFSFY
GGGLSPADAA TPALFEILKA VSCSKDASEE RCALLKEQFL RLARYRQLKT LEDYQALAEH
IGRELQQEGI TEAGRLFYLS LPAFAYVDVA DKINRSCRPT GGPWLRVVLE KPFGHDIRSA
EVLATQLEGS LKDEEMYRID HYLGKQVVAK ILPFRVENKK FLDPIWNKHH IERVEIVMKE
TLDVKGRISF YDQYGVIRDV LQNHLTEVMT LLMMRLPTNL SSSEEILQRK LQIFSSMLPL
RKNQAVVGQY QAYQTTVQQE TNKTKDHVSR TPTYAAVLAH IDEAQYEGVP ILLISGKMLD
ERVGYARILF KNDVFCLQSR DGVHCKPKQI VFYFGHGSLQ YPAVLVSKNL FRPVVTDSEW
TEVTEHTDVN ILGLPISDYY VQTPTEQKEA YSELISQIFA GCKNNFISTE NLLASWGLWT
PLLNSLAGTY PRIYPGGGDN RDLLDIRVNG KDVGYTREVV IISPEQMGAT SANSFQVMQG
NFRRADMVSA WPEELVERLA ADIQKEAEAA VREGNVFHLA ISGGSTPLAL FHRLALHHFS
FPWSHTHVWM VDERCVPLTE PESNFRGLHD HLLQHVRIPY FNIHPMPVQL NQRLCVEEDR
GAALYEKEIS GMVHGSSFHF VLLGVGYDGH TASLFPGGKA DEVGEGLVAL TESPLKPHQR
MSLTFSAINR ARTVALLVMG KGKHELISQL SRVSDKPDKW PVTGVKPADG RLVWYIDYDA
LLG
//