ID G3PF48_GASAC Unreviewed; 812 AA.
AC G3PF48;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Nibrin {ECO:0000256|ARBA:ARBA00020013, ECO:0000256|PIRNR:PIRNR011869};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000016222.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000016222.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000016222.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the MRE11-RAD50-NBN (MRN complex) which plays a
CC critical role in the cellular response to DNA damage and the
CC maintenance of chromosome integrity. The complex is involved in double-
CC strand break (DSB) repair, DNA recombination, maintenance of telomere
CC integrity, cell cycle checkpoint control and meiosis.
CC {ECO:0000256|PIRNR:PIRNR011869}.
CC -!- SUBUNIT: Component of the MRN complex. {ECO:0000256|PIRNR:PIRNR011869}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR011869}.
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DR AlphaFoldDB; G3PF48; -.
DR STRING; 69293.ENSGACP00000016222; -.
DR Ensembl; ENSGACT00000016254.1; ENSGACP00000016222.1; ENSGACG00000012254.1.
DR eggNOG; ENOG502QQ7Y; Eukaryota.
DR GeneTree; ENSGT00390000000521; -.
DR InParanoid; G3PF48; -.
DR OMA; KKNFKMF; -.
DR TreeFam; TF101103; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000012254; Expressed in embryo and 13 other cell types or tissues.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0030870; C:Mre11 complex; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd17741; BRCT_nibrin; 1.
DR CDD; cd22667; FHA_NBN; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.10980; Nibrin, BRCT2 domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR040227; Nibrin-rel.
DR InterPro; IPR032429; Nibrin_BRCT2.
DR InterPro; IPR043014; Nibrin_BRCT2_sf.
DR InterPro; IPR013908; Nibrin_C.
DR InterPro; IPR016592; Nibrin_met.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR12162:SF0; NIBRIN; 1.
DR PANTHER; PTHR12162; NIBRIN-RELATED; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF08599; Nbs1_C; 1.
DR Pfam; PF16508; NIBRIN_BRCT_II; 1.
DR PIRSF; PIRSF011869; Nibrin_animal; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM01348; Nbs1_C; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
PE 4: Predicted;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR011869};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|PIRNR:PIRNR011869};
KW DNA repair {ECO:0000256|PIRNR:PIRNR011869};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254, ECO:0000256|PIRNR:PIRNR011869};
KW Nucleus {ECO:0000256|PIRNR:PIRNR011869};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|PIRNR:PIRNR011869}.
FT DOMAIN 22..70
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 411..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 89838 MW; AE7ED2E420BCF3B5 CRC64;
MWILTPLEPG GETHYLVSCK EYVVGRKNCD ILLPNDQSIS RAHACLTAAD QTLTLKDTSK
YGSFVNSQRS PENTPVGLKS GDNVTFGVFQ HKFSVEHQKP VVCSSCLDND GKASISQALL
ALGGKLVNNW TDDCTHLAMP SAKVTIKTIS ALLCCRPIVK PDFFTEFCEA ARQKSPPPKA
ERFIPEIDEP SLRNDDVNLA AIPVRRQLFS GKTFIFLNAK QLRRLSTAVS FGRGESRLLE
EGSLPRDLLE SPHSCVIDVM TASSQTLPFS TTEWVNSVKN IVQRKGLRVI TESEIGLAAI
YASCNKYCNP SCLTPDSESA PEVAPRIPTS SLSQSAAVDE TALPAASQNI TAYAANTEPS
QGKDACEGTR VMAVGETPEE TQNQNSSQAG GFRPFAKKTF TQCVVPDTMS SSFNSAESTH
SQMKKPESKT TVSGAGSSGI RSRTALPRSN VSRSAQGSPQ KQLTLTTFFQ NANKKRPLEE
ELFSVTSEPK RSALESSISM QTPNASAKSK ETSSRSVRAP VAKSQAALRP AANLLAGRPE
AQSDRAAQEE PRSRKRKEME EEIEMDELES LMSEDFFDDQ PTVNQGRQAP PTTLGSTEPK
QRLDSEEASS SSKRQRVHLE ENVKSQRPQV GLEKNKEQRS DQDVFTIKTE QVHPLEYETD
VKSSVRPEVS SASTSKDLLP FEDDDESFIE VRIYFVFFHP ETKIDEDLPN RLVLVEFRSL
TVTAPPRTRP PRMQNKGHAK NFKCFQKIYV TSAQRSPHII GGSDLLVHSR GKNSDLDEFL
KDAVEEERQS RRDESVGDDL FRYNPTKQTR RR
//
