ID   G3PFM0_GASAC            Unreviewed;       900 AA.
AC   G3PFM0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Dynein, axonemal, heavy chain 2 {ECO:0000313|Ensembl:ENSGACP00000016394.1};
GN   Name=DNAH2 {ECO:0000313|Ensembl:ENSGACP00000016394.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000016394.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000016394.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000016394.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3PFM0; -.
DR   Ensembl; ENSGACT00000016426.1; ENSGACP00000016394.1; ENSGACG00000012383.1.
DR   GeneTree; ENSGT00940000157623; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000012383; Expressed in mesonephros and 1 other cell type or tissue.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR45703:SF32; DYNEINS HEAVY CHAIN; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          9..272
FT                   /note="Dynein heavy chain coiled coil stalk"
FT                   /evidence="ECO:0000259|Pfam:PF12777"
FT   DOMAIN          302..523
FT                   /note="Dynein heavy chain ATP-binding dynein motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12781"
FT   DOMAIN          770..883
FT                   /note="Dynein heavy chain region D6 P-loop"
FT                   /evidence="ECO:0000259|Pfam:PF03028"
FT   COILED          158..220
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   900 AA;  102196 MW;  3690AD4ACF965661 CRC64;
     MSVELEEAKK QVAVFQIQCD EFLSIILEQT TEANKQKNAL ESLNKRDMTE IKSYGCPPAL
     VETVMQAVMT LLGKEATWAE AKRQLGDSNF IKTLVNFDKD NITERVLKDI GQFCRQVDFQ
     PEIIGKVSLA AKSLCMWVRA MEVYGRVYRV VEPKRAQLNA AMAQLVEKQT QLAAAQDKLR
     EVGEKKEQLE KELGEKLIMK KSLREKSEEM EMKLDRADKL VTGLAGERVR WEERVAVLEE
     NMGYLVGDCL LAASFLSYMG PFLSNYRDKL LAIWMKEVRD LAIPCTPGFS FAVFLSKPTV
     VRDWNIQGLP SDAFSTENGV IVTRGNRCPL MVDPQGQSMK WIKNMEMKRG LKVIDFQMPD
     YLRVLENAIQ FGTPVLLQNI LEDLDPSLDP ILNKSITRIG GRLLMKLGDK EVEYNPEFRF
     YITTKLSNPH YTPEISTKTI IVNFGVMEQG LEAQLLGIVV RKERPELEEQ KDSLVISIAS
     GKRSLEDLED EILRLLNEAT GSLLDDEQLV KALQASKVTA TEVSEQLESS EQTEINIDSA
     REAYCPCAQR ASILFTILND MGRIDPMYQF SLDAYIDLFN LSIKKSERSH ELQERIAYLN
     EYHTCAVYSY TCRGLFECHK LLLSFQMCAR ILEVAGKLNI DEYNFFLRGG LVLHDEYQLK
     NPCSSWLVES SWDNITELDK LPKFNGIAGS FKKDHAKWNL WFTSAEPEKA KLPDNWDFNC
     NEFQKMLIVR SLRQDRVSLC VTSFIVNNLG QHFVEPPVLD MKAVVEESTC RTPLIFILSP
     GVDPTGALLQ LAEASGMSKH FHALSLGQGQ APIAKSMIEE GVKNGHWVFL ANCHLSLSWM
     PELDKLVEQL QVQEPQSKFR LWLSSSPHPG FPITILQAGI KMTTEPPKGV KANMKRLYQQ
//