ID G3PGN5_GASAC Unreviewed; 322 AA.
AC G3PGN5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=F5/8 type C domain-containing protein {ECO:0000259|PROSITE:PS50022};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000016760.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000016760.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000016760.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a defensive agent. Recognizes blood group fucosylated
CC oligosaccharides including A, B, H and Lewis B-type antigens. Does not
CC recognize Lewis A antigen and has low affinity for monovalent haptens.
CC {ECO:0000256|ARBA:ARBA00002219}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000256|ARBA:ARBA00011233}.
CC -!- SIMILARITY: Belongs to the fucolectin family.
CC {ECO:0000256|ARBA:ARBA00010147}.
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DR AlphaFoldDB; G3PGN5; -.
DR STRING; 69293.ENSGACP00000016760; -.
DR Ensembl; ENSGACT00000016794.1; ENSGACP00000016760.1; ENSGACG00000012682.1.
DR eggNOG; ENOG502QQVA; Eukaryota.
DR GeneTree; ENSGT01060000248575; -.
DR InParanoid; G3PGN5; -.
DR OMA; CHTRING; -.
DR TreeFam; TF343744; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000012682; Expressed in spleen and 11 other cell types or tissues.
DR GO; GO:0042806; F:fucose binding; IEA:UniProt.
DR GO; GO:0010185; P:regulation of cellular defense response; IEA:UniProt.
DR GO; GO:0001868; P:regulation of complement activation, lectin pathway; IEA:UniProt.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR006585; FTP1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR45713; FTP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45713:SF8; V-FBPL-RELATED; 1.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR SMART; SM00607; FTP; 2.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR PROSITE; PS50022; FA58C_3; 1.
PE 3: Inferred from homology;
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 169..321
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
SQ SEQUENCE 322 AA; 35603 MW; D001D41D3D91F738 CRC64;
CFVICFFMQI NYLNVGSFFS KKKNVAMRGK ASQSSRIDSG FSAAYNSIDG NRNPHFKSGS
CSHTMQQTNP WWRVDLLHPY MVTSIIISNR ADCCKERLNG AKVHVGNSLD DNGAANPVCA
VITSVPPGGV SEFRCNGMDG RYVNVFIPRK EYLTLCEVEV YGSPLDKYIS QTALGRNRKN
VALRGKATQS TRYGDEYGAA YNAIDGNRNS FWLAGSCTHT NEETGPWWRV DLLRPYTVTS
IAITNRADCC EERLNGAKVH VGNSIKNNGA ANPVVGTVDR TDQGELITLT FTEHVEGRYV
TVVLPGSGKY LTLCEVEVYG YR
//
