ID   G3PHE2_GASAC            Unreviewed;       740 AA.
AC   G3PHE2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Mitofusin 2 {ECO:0000313|Ensembl:ENSGACP00000017017.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017017.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000017017.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000017017.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC       outer membrane {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004374}.
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DR   AlphaFoldDB; G3PHE2; -.
DR   Ensembl; ENSGACT00000017051.1; ENSGACP00000017017.1; ENSGACG00000012833.1.
DR   GeneTree; ENSGT00390000013727; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000012833; Expressed in diencephalon and 13 other cell types or tissues.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0008053; P:mitochondrial fusion; IEA:InterPro.
DR   CDD; cd09912; DLP_2; 1.
DR   Gene3D; 1.20.5.110; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR006884; Fzo/mitofusin_HR2.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027094; Mitofusin_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10465:SF1; MITOFUSIN-2; 1.
DR   PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   Pfam; PF04799; Fzo_mitofusin; 1.
DR   SUPFAM; SSF111479; Fzo-like conserved region; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        609..627
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          73..322
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   COILED          680..707
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   740 AA;  83817 MW;  161FD45CCA1F684C CRC64;
     MAEVNASPLK HFVTAKKKIN GIFEQLGVYI KESASFLDDT HKNEELDPVT TEEQVQEVRG
     YLAKVAGIGE VLARRHMKVV FFGRTSNGKS SVINAMLCDK VLPSGIGHTT NCFLRVEGTD
     GNEAFLLTEG SEERKSIKTV NQLAHALHQD EDLDAGSLVC VMWPKAKCAL LRDDLVLVDS
     PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKSF FHKVNERLSS PNIFILNNRW
     DASASEPEYM EEVRRQHMDR CTNFLVDELG VVDRAQASDR IFFVSAKEVL QARVQKAQGM
     PEAGGALAEG FQARMFEFQN FERRFEECIS QSAVKTKFEQ HTVRAKQISE ALRRIMDSVH
     IAAQEQRIYC LETKEDRQDR LEFIDKQLDL LSMDCKAKIK KITEEVERQV SNAMSEEIRK
     LHVLVDDYHM DFHPSPVVLK VYKNELHRHI EVGLGKNMSE RCSTSITSAL QATQTDMIDG
     LKPLLPNPVR EQVDKLVPRP CFNLSYDLAC DKLCSDFQED ISFHFSLGWT MLVNRFLGPK
     NTRRALMGYS DQVPRPMALT PVSTSMPPFP QSSVTQEELM VSMVTGLASL TSRTSMGVLV
     VGGVVWKAVG WRLIALSVGL YGLLYIYERL TWTTRAKERA FKRQFVDYAS EKLQLIVSYT
     GSNCSHQVQQ ELAGVFAQLC QQVDVTRQNL EDEITDMNSK IELLDGLQSK AKLLRNKAGW
     LDSELNMFTQ QYLHHSNQHL
//