ID G3PI22_GASAC Unreviewed; 729 AA.
AC G3PI22;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Bromodomain-containing protein 2 {ECO:0000256|ARBA:ARBA00040998};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017249.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000017249.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000017249.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. Interacts with E2F1 and with histone H4 acetylated
CC at 'Lys-13'. {ECO:0000256|ARBA:ARBA00038820}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3PI22; -.
DR Ensembl; ENSGACT00000017283.1; ENSGACP00000017249.1; ENSGACG00000013037.1.
DR GeneTree; ENSGT00940000153385; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013037; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 67..139
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 321..393
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 561..643
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 25..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 281..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 479..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 81595 MW; AC04A8A92EFCFAD5 CRC64;
MDQHSSSGKR IRKPSLLYED FESPSLAHTL PQGPPVPPQP PVKDASRPGR MTNQLQFLQR
TLMKYLWRHQ FAWPFREPVD AYRLSLPDYH KIIKQPMDMG TIKKRLENGF YRSASECIQD
FNTMFTNCYI YNKPTDDIVL MAQPLEKIFL QKVAQMPQDE VELPPPAPRS KNSRGRGRKS
SSRAQQVPAV SQSAYSPSSS DTGESMLASS PQTVLTKSLP PANIMGLPPT QPTTKKKGVK
RKADTTTPST MGLTVGMSAG GPVLLQPMMA GGGRRVGSGR PIKPPKKDLP DSVHAQPSKK
GKLSPQLRYC SGLLKDMLSK KHAAYAWPFY TPVDAAALGL HDYHDIIKCP MDLSNIKRKM
DGREYRDAQQ FASDVRVMFS NCYKYNPPDH DVVGMARKLQ DVFEFRFAKM PDEPRMDHGA
PSLGGHQESE PCSESEESES SPNSDSEEER AHRLAELQDQ LRAMHEQLAA LSQGPIIKEK
RSRAVRSRAD SEEWKMPGKI LKSKSARANG PPPKKSQGKK SSKGLTRVVF VPDRAPSPSS
RRATKKPFYP PPPTSMLPHY DSEEEEEIVP MSYDEKRQLS LDINKLPGEK LGRVVHIIQS
REPSLRDTNP EEIEIDFEML KPSTLKELER YVMTCLRKKP RKPYGGEAAA GMKGGAGKSK
EELALEKRME LERRLQDVSG QLNSVKKPTK PKVSSAEKPS AVETHSQPSH LSGSSSSCLV
LFFFFFTVF
//
