ID G3PI46_GASAC Unreviewed; 318 AA.
AC G3PI46;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Deoxyribonuclease-1-like 1 {ECO:0000256|ARBA:ARBA00041152};
DE AltName: Full=DNase X {ECO:0000256|ARBA:ARBA00043073};
DE AltName: Full=Deoxyribonuclease I-like 1 {ECO:0000256|ARBA:ARBA00042003};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017273.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000017273.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000017273.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNase I family.
CC {ECO:0000256|ARBA:ARBA00007359}.
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DR AlphaFoldDB; G3PI46; -.
DR Ensembl; ENSGACT00000017307.1; ENSGACP00000017273.1; ENSGACG00000013035.1.
DR GeneTree; ENSGT00950000182846; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013035; Expressed in spleen and 13 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0004536; F:DNA nuclease activity; IEA:InterPro.
DR GO; GO:0006308; P:DNA catabolic process; IEA:InterPro.
DR CDD; cd10282; DNase1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR018057; Deoxyribonuclease-1_AS.
DR InterPro; IPR016202; DNase_I.
DR InterPro; IPR033125; DNASE_I_2.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR PANTHER; PTHR11371; DEOXYRIBONUCLEASE; 1.
DR PANTHER; PTHR11371:SF28; DEOXYRIBONUCLEASE-1-LIKE 1; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR PIRSF; PIRSF000988; DNase_I_euk; 1.
DR PRINTS; PR00130; DNASEI.
DR SMART; SM00476; DNaseIc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR PROSITE; PS00919; DNASE_I_1; 1.
DR PROSITE; PS00918; DNASE_I_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR000988-2};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..318
FT /note="Deoxyribonuclease-1-like 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003449665"
FT DOMAIN 29..278
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT ACT_SITE 104
FT /evidence="ECO:0000256|PIRSR:PIRSR000988-1"
FT ACT_SITE 159
FT /evidence="ECO:0000256|PIRSR:PIRSR000988-1"
FT DISULFID 198..235
FT /note="Essential for enzymatic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000988-2"
SQ SEQUENCE 318 AA; 36708 MW; 65AB2923B0A98E74 CRC64;
MRASFLLLLL TFLVGLCDVE GDTDFRVCAF NLHHFGDSKS KKTNVMHTLV RIIARCDVCL
LQEVRDSQEL AVPQLLRRLN SYDPEHDYAS VSSERLGRTA SYQEQYVFVY RTDTATLTGQ
YQYPDDRPGD VDAFAREPFV VRFNAPRTDI REFVLIPQHT TPTNTTKELD ALYDVLQHVK
TMWETEDVML LGDFNADCAY LAKKNRKYVR LLTQSELYWL IPEKADTTVR STTSCTYDRI
VVHGERFSRA IVPFSAKPFN FQLEYRLTEE QALEVSDHYP VEVLLKDIAY KVVSAATYKF
PSLSLFVLVH HVFQALMS
//
