ID G3PIC4_GASAC Unreviewed; 671 AA.
AC G3PIC4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 2 {ECO:0000313|Ensembl:ENSGACP00000017351.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017351.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000017351.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000017351.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3PIC4; -.
DR STRING; 69293.ENSGACP00000017351; -.
DR Ensembl; ENSGACT00000017385.1; ENSGACP00000017351.1; ENSGACG00000013112.1.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000167370; -.
DR InParanoid; G3PIC4; -.
DR OMA; IQQWLRG; -.
DR TreeFam; TF315204; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013112; Expressed in spleen and 13 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF350; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 2 ISOFORM X1; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 31..154
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 188..447
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 555..639
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 160..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 74892 MW; 341556454050FD0C CRC64;
TVVEEQDDGV IYTVVVKQQH GAPTSPASVS RSQCVKAGTE EKLVLHLLHS FSMGDSSFIT
IFLSTYRSFT STGRVLDILT DRWESVLSVI QENIVRDLKA VCTVFSTWLS EYPEDFKSLE
EPSRLLRLVP LLPQDSSSAA DLSARILRIA EALSEKALLP DARKDHTGPT GPPPDASKFE
PTSVLGFPAA LIAEQLTRLE TELFVRLVPY HCLGSLWSQR DKKGREGVCW SVRATIRQFN
KLANAVLASC LWPTGLRSQQ RARLLEKWIS VAEECRARKN FSSLYAIVSA LQSNPIHRLR
KTWQDTDREA VRRYEELSEI FSDKDNYSQS RELLKEVSFR PSVISMLKKE NYSHRGTNAQ
GTVPYLGIFL TDLTMLDTAV KDRLDNGYIN FDKRRREFEV LAQIRLLQSS CKNCVFTTDE
AFARWYQSVP LLTEAESYRL SNEIEAPGEP SPRGVPPTVI ITQCPNLSTS RNSLTGDSDS
LFDFPSPVNN LLSKLTKHMK SPSVSCLDVD TSSSTNDSTP AALTPSTPTK SHRRSISCGN
NPPNNIQGSG PEMRIIRIRM DLQDGNLYRS ILVTSNDKSP TVISSALEKH NQDPKQTSRY
ELIQLLPEGK AELVIPATGN VFYAMSSSSV DFLLRRKGGI APPGSQPINT ETSATFPRIK
AKGRRLVRTL F
//
