ID G3PIH3_GASAC Unreviewed; 553 AA.
AC G3PIH3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN Name=ANO2 {ECO:0000313|Ensembl:ENSGACP00000017401.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017401.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000017401.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000017401.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR AlphaFoldDB; G3PIH3; -.
DR Ensembl; ENSGACT00000017435.1; ENSGACP00000017401.1; ENSGACG00000013149.1.
DR GeneTree; ENSGT00940000155840; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013149; Expressed in camera-type eye and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF20; ANOCTAMIN-2; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 132..158
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 178..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 220..237
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 348..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 504..525
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 28..538
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT COILED 295..322
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 553 AA; 63984 MW; B9371AF76F6CA729 CRC64;
QETCDDNLNI TMCPLCDGVC DYWRLSTVCS LARASYLFDN GVTVLFAIFM SLWAAYFLEH
WKRRQMCLKH TWDLTSLEDE EDRVQEELRP EYEEVLQEKK AKMKAQSKKK REPESLDIED
HLSGYLINVS TLLLLIFVTF SAVVGVAVYR ICMLSVWSMN PDPEAKASVR MTVTTTGIIL
NMLVVLVLEE VYGAIAVWLT ELELPKTKEE FEEKLIFKSF FLKSMNAFAP IFYVAFFKGR
FGGRPGDYVY VFGDYRMEEC APPGCLIELC IQLSMIMLGK QLIQNNVFEV LIPKLKKMYR
TIQEEKVKKR AAENEENATE EKRPKQQFDK DYALEPYEGV TPEYMEMIIQ YGFVSLFVAS
FPLAPAFALL NNVIEIRLDA AKFVTEIRRP DAVRCKDIGI WYNILCGISK FSVITNAFVI
SFTSEFVPRM VYQYMYSVNG TMNGYTEHSL SYFNVSNFPP GSAPTTALVT GVSMCRYKDY
RDPPWDTEAY TFSKQYWSVL AAKLAFVIFF QNFAMFLSML VAWMIPDVPR SLREQLMKEN
MMLMEFLLNQ DQE
//
