ID   G3PIJ5_GASAC            Unreviewed;       757 AA.
AC   G3PIJ5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Myotubularin related protein 11 {ECO:0000313|Ensembl:ENSGACP00000017423.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017423.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000017423.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000017423.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR   AlphaFoldDB; G3PIJ5; -.
DR   STRING; 69293.ENSGACP00000017423; -.
DR   Ensembl; ENSGACT00000017457.1; ENSGACP00000017423.1; ENSGACG00000013174.1.
DR   eggNOG; KOG1089; Eukaryota.
DR   GeneTree; ENSGT00940000160276; -.
DR   InParanoid; G3PIJ5; -.
DR   OMA; GWQRSQD; -.
DR   TreeFam; TF315197; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000013174; Expressed in telencephalon and 8 other cell types or tissues.
DR   CDD; cd14595; PTP-MTMR11; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR022587; MTMR12-like_C.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF51; MYOTUBULARIN-RELATED PROTEIN 11; 1.
DR   Pfam; PF12578; 3-PAP; 1.
DR   Pfam; PF06602; Myotub-related; 2.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          141..596
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
FT   REGION          439..468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          631..757
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..466
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..672
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..705
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   757 AA;  84379 MW;  A985C6AC5C01A1A9 CRC64;
     MVRKKLTARE GRGWVSGTLF CTHFRVAFVP QDNADPVLLG DHDVALASIE KVVVVGPNRT
     KLVTPNSSLK FTPEELVLYC RDLRVICFLF DRLTPDAQVI EITYTIAKTY QPPKPGSVLS
     FQNAALGSVG NRRRDTHMNW FESASDWEQE LERCGATGWR VSSVNDRFEM STSLPRSIVV
     PQKVLDTELK KSFAHFHEGR IPRWCWRHPR GSDLLRMAGF QNNIYHEKDD IKNLEMILFG
     CQSSLCVVVE LDEELPSPAD IQLSHGRLRA LCLGDISTSV SVPDDRWLST LESTHWLDYT
     RACLRKASEV ACLLRGGHLT VALQEADDRD MGCVVSSLVQ VMCDPHCRTQ RGFQGLVQKE
     WVMAGHRFSS RINYHRDNDK EEAPVFLLFL DCVWQISSQY PTRFQLTEDF LLALHDSIHL
     PLFSSFLANC QRERCKRSQS TQNLGQSYTP VNGWRDVDSS SDPSDPPLPS VWDWSLQYSK
     HRRDRFTQPV PPIPSLQPPS DTVPGSVFLL SRGTFSCPVN LLPWRAGSSG VYKKSHRRAA
     SSENVPGLER LLKAWAMAEL PQGVTSTSAP QGPLDPYEPL LPLLMGPCMG LWKECYLRGA
     LHAQAFSHPV SANHPHPVER LAREVQQLKD ELARASSGAD PIPPPKTAEP RRTDTNLNQN
     ANNGTFLFPA SRPQSASAPR AAPPPSSANR QTSRGPPPPP ASAPPSRHGH HRDNGGGNKH
     TFLFGHPPAA EPRPDQRYYP APNAAKLPKS NGSSVAS
//