ID   G3PJU1_GASAC            Unreviewed;       901 AA.
AC   G3PJU1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Chloride channel, voltage-sensitive 2a {ECO:0000313|Ensembl:ENSGACP00000017871.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017871.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000017871.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000017871.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; G3PJU1; -.
DR   STRING; 69293.ENSGACP00000017871; -.
DR   Ensembl; ENSGACT00000017906.1; ENSGACP00000017871.1; ENSGACG00000013518.1.
DR   eggNOG; KOG0476; Eukaryota.
DR   GeneTree; ENSGT00940000155439; -.
DR   InParanoid; G3PJU1; -.
DR   OMA; EAQKWMH; -.
DR   TreeFam; TF300522; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000013518; Expressed in telencephalon and 1 other cell type or tissue.
DR   GO; GO:0030054; C:cell junction; IEA:Ensembl.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR   CDD; cd03683; ClC_1_like; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 2.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   PANTHER; PTHR45720:SF14; CHLORIDE CHANNEL PROTEIN 2; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   4: Predicted;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW   Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW   Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT   TRANSMEM        98..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        141..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        248..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        373..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        441..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          666..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        675..693
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   901 AA;  99054 MW;  B397F493AF6F90F9 CRC64;
     EAPPAGAEAE EELSDSAEAF SCTQMYGRYT QELGVYAKEE AARLRDGGVR DGAGLRRNTS
     VRSRAADLLE YEKDPCAKCH LCASRCQKFL ISRVGEDWIF LILLGLLMAL VSWVMDYAIA
     FCQEAQKWMY GGLDSNMLLQ YIAWVTYPVV LITFSAGFTQ ILAPQAVGSS GIPEMKTILR
     GVVLKEYLTF KTFVAKVIGL TCALGSGMPL GKEGPFVHVA SLCAALLSKF MAPLFGGIYM
     NELRNTEMLS AACAVGVGCC FAAPIGGVLF SIEVTSTFFA VRNYWRGFFA ATFSAFIFRV
     LAVWNQEEET ITALFKTRFR LDFPFDLQEL PAFAILGIAC GFGGALFVYL NRLIVECMRK
     QKTINKFLLR KRLVYPALVT LLISTLTFPP GFGQFMAGQL TQHESLVALF DNRTWCRHGV
     AEEFDYVSHH HHAWKHPQVN VFITLVLFIV MKFWMSAVAT TMPVPCGAFM PVFLIGTGAA
     FGRLVGEIMA TMFPDGIHAD GSVYPIVPGG YAVVGAAALS GAVTHTVSTA VIVFELTGQI
     SHILPVMIAV ILANAVAQSL QPSLYDSIIR IKKLPYLPEL GMGHHEKYNI RVEDIMVRDV
     RYITLTSCYR DLQEMLVTAQ LKTLALVESR DSMILLGSIE RLQLQSLLSL QLSRLRRLEY
     LRQLAQDNGG RDRPASRTTD STPSSPCARV NSSSNARQAV RFLVSAQQGC LNTVATGTPP
     SGRRTGIRLK MAKCCLPGWK SPAGPTPPEP GPKRVRISMA DSPDGEDGMT PSDVAEWEEQ
     QLDEPVDFKN CKIDPAPFQL VEQTSLHKTH TIFSLLGLDH AYVTSMGRLV GVVSLKELRK
     AIEGSVTVTG VKVRPPLASF RDNGNNANVS EVTELHKLCI RHRGLSLPRE PNPPDVEDQA
     D
//