ID G3PMN7_GASAC Unreviewed; 1606 AA.
AC G3PMN7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Unc-13 homolog Ba (C. elegans) {ECO:0000313|Ensembl:ENSGACP00000018868.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000018868.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000018868.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000018868.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 69293.ENSGACP00000018868; -.
DR Ensembl; ENSGACT00000018906.1; ENSGACP00000018868.1; ENSGACG00000014286.1.
DR eggNOG; KOG1011; Eukaryota.
DR GeneTree; ENSGT00940000165775; -.
DR InParanoid; G3PMN7; -.
DR OMA; HERHKLC; -.
DR TreeFam; TF312844; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000014286; Expressed in camera-type eye and 2 other cell types or tissues.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd08394; C2A_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF14; PROTEIN UNC-13 HOMOLOG B-LIKE; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..97
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 488..538
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 594..719
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1022..1165
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1267..1405
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1438..1561
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 191..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..209
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1606 AA; 182732 MW; 44AC5284B2617869 CRC64;
VFSLCLPVKK AKLHGPPDKF NAYVTLKVQN VKSTTVTVRG DQPCWEQDFM FEINHLESGL
VVELWNKGLI WDTMIGTALI PLDSIGQSDE EGPGHWTSLD SEVLMREDEI CGTSNPTPHQ
VLLDTRFELP FDIPEDEAQY WSGKLDRINT MRIHDEYPLQ EEVRRGRMAS VPSQCCSWSY
FGWNDQQTLD DHDSAVDDRD SDYRSETGSR PPRFHNTPQT NSSVHQYPVG RRAQHPTPSG
EADSIRSYEL DYREIRRPSR QSKKAHLLEA MNPSKSLKTN PLGLERAQKQ NDSHQETKTS
YSAHESIDLS NRGESPERQN PLLVTYLDAE EEAGEQQVEK EQNAPPEPGS NKDLKDSLVI
SPQPTETKVC FFEDGPPPCS PSKVRWLKAY NKVRVRLLES RDQGGDPSKH PWAKPGRGNT
PFGIDSMPDL RKRRPIPLVS ELSMIQTRKA GLAHTLSTRT SLKDEELKNH VYKKTLQSLI
YPISCTTPHN FEVWTATTPT YCHECEGLLW GIARQGMRCA ECGVKVHEKC QELLNADCLQ
RAAEKSSKTG AEDRTQHIIM AMKDRMKIRE RNKPEIFEEI RKVFNAPRVI HVQHMKTVKQ
SVLDGTSKWS AKIAINAVVS AQGLQAKDRT GSSDPYVTIQ VGKTKKRTKT IYGNLNPVWE
EKFSFECHNS SDRIKLRVWD EDDDIKSRVK QRLKRESDDF LGQSIIEVRT LSGEMDVWYN
LDVVDKSAVS GAIRLQISVE IEGEEKVAPY HVQYTCLHEN MFHFSTDVEG GGVVKIPAAH
GDDAWKVYYD EVKQDIVDEF AMRYGIESIY QAMTHFSCLS SKYMLSGVPA VMSTLLANIN
AFYAHPTAST NVSAPARFAA SNFGRDRFVK LLDQLHNSLR IDLSMYRNNF PASSKPRLHD
LKSTVDLLTS ITFFRMKVWE LQSPPRAAHV VDCFKPRLTS PYEFFNTCLE LFNRQFPTRR
STEQEEQGPS IQNLDFWPKL ITLMVSIIEE DKNSYTPIIN QFPQELDVGK VSTEVMWRLF
AQDMKYALTE HEKHKLCKTA DYMNLHFKVK WLYNEYVKDL PTFTDAVPEY PAWFLPFVLA
WLAENEDVSM EFMHGALERD KREGFQQTSE HALFSSSVVD IFTQLNQSFE IIKKLDCPDP
AVVAQYNRRF AKIFNLHLTL FLCSLSLSFK TESKKEKLPC MFRRNRAQLP RLRTRRFAAS
HVRELDTEAA DILNELQVKL NTHLDNFSIV FAKSFQARIN SCMRQMAEIL YQIKGPPNHS
TAEADADNML RPLMEFLDGN LSIFADICEK TVLKRILKDL WKTVLSSLEK SIVLPQSNDS
LGAQLLTAAK GLSNLKSLQG GGEAKTLTPK QCIIIDAGLE TIKQYFHAGG NGLKKTFVEK
SPELASLRYA LSLYSQSTDA LIKTFVTTQH SQVHDGMGIR ITGSEKIRPD RGPGVEKPIG
EAVLQIDMML GKERKVSVRV IAVNDMKWQT SGMFRPFVDV SMVGPFLADK KRKFTTKSKN
NSWSAKFNEA FQFVLGKESP DCYELQVTVK DYCFGRADRV VGVAVLQLRD VADRKSCVCW
CPLGPRVHTD ETGLTVMRIL SQRPADEVAK EVVRLKAETR PAEEGR
//
