ID G3PP91_GASAC Unreviewed; 1010 AA.
AC G3PP91;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
GN Name=HIRA {ECO:0000313|Ensembl:ENSGACP00000019424.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000019424.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000019424.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000019424.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR AlphaFoldDB; G3PP91; -.
DR STRING; 69293.ENSGACP00000019424; -.
DR Ensembl; ENSGACT00000019462.1; ENSGACP00000019424.1; ENSGACG00000014707.1.
DR eggNOG; KOG0973; Eukaryota.
DR GeneTree; ENSGT00550000074919; -.
DR InParanoid; G3PP91; -.
DR OMA; RGSWDGD; -.
DR TreeFam; TF323161; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000014707; Expressed in muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 64..96
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 125..166
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 168..199
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 757..955
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 484..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..605
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 110651 MW; 05439BFBFA4B06C1 CRC64;
MKLLKPSWVS HNGKPIFSVD IHPDGTKFAT GGQGEDSGKV MIWNMPVLRD EDEKNESIPM
LCQMDNHLAC VNCVRWSNNG LYLASGGDDK LVMVWKRAAF IGPSTVFGSS SKLANVEQWR
CVTILRNHTG DVMDVAWSPH DVWLASCSVD NTIVIWNARK FPEMVTCLRG HTGLVKGLTW
DPVGKYVASQ ADDHSLRVWR TVDWQMESNI TKPFNECGGT THVLRLSWSP DGQYLVSAHA
MNNSGPTAQI VERDGWKTNM DFVGHRKAVT VVKFNPKIFK KKQKNGSAPK PGCPYCCCAV
GSKDRSLSVW LTSLKRPLVV IHDLFDKSIM DISWTLTGLG MLVCSMDGTV AYLDFSLDEL
GDPLNEEEKV RPSSSSSLCG LKVFPEFLRT RMNRPRCLSV RYEQAQMFVG EVRTGPDVCA
VRYEQAQMFP QLKQMSLQNL LKKQVETRTP DGRRRITPLC IAQLDTGDFS PALFNSAPIL
PSGSSMSNQL TSQLSSDSSP GPSSSLGLRP GHDPMLTSPP AGAAKGPEDN REGVKSGLLL
TSASKMEPMK ALDSRFTERS KATPGVTAAI TSITGLLPLD SRLKDGVPGP KDAKSKEDSS
SDSEDKMASI NKNLSFSKRK PELLMEGGEG VVEKRRKGRP RKDKMAVPSA QPFPQATPPA
EQHSRVAPPP TAALKLPTPS IKKAFSLQVS AEPPVFLEVE NEVSLVAGSK LSQLRCSRDG
REWNTLLPSS VVTAAGSSDV LAVACQDRML SVFSSCGRRL LPAIQLATPT SALHCSAHFV
MALTAGATLS VWDVQKQKAL VKNESLLSIL SGADATVSQS LLTQQGVPVI GLSNGKSYCF
SSSLETWTLV ADKGDSMVQC ADFRSCLPTH DAPVSSGPLA VMQGRNLNAG RLASRLSSTP
HHLQQSMTLA FLENQLTSAL TLQSAAEYRH WLLIYARFLV SEALKNRLRE LCKELLSPVN
KSAATAWEPS TLGLRKRELL REVLPVMVEN LRFQRLFTEY QDQLELLRTK
//
