ID G3PQL7_GASAC Unreviewed; 842 AA.
AC G3PQL7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Cadherin-4 {ECO:0000256|ARBA:ARBA00041040};
GN Name=CDH4 {ECO:0000313|Ensembl:ENSGACP00000019902.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000019902.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000019902.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000019902.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; G3PQL7; -.
DR STRING; 69293.ENSGACP00000019902; -.
DR Ensembl; ENSGACT00000019940.1; ENSGACP00000019902.1; ENSGACG00000015086.1.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000158073; -.
DR InParanoid; G3PQL7; -.
DR OMA; DYVCNIN; -.
DR TreeFam; TF316817; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000015086; Expressed in diencephalon and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 3.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF81; CADHERIN-4; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 4.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 662..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 107..214
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 215..329
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 330..540
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 539..650
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 403..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 92406 MW; 299C9B5E3CDD10E2 CRC64;
VEFDDCAGND AVVFRSSDPN FGARADGSIF ARAEGAGLDR PVQFKLTASG PHTGAWETVV
QLALIEPPSL RLHGNERSGD SSRQESATLL LCSRPNGSKG LRRQKRDWVI PPINVAENSR
GPFPQMLVSI RSDQDKDISI RYSITGVGAD QPPNEVFNID PVLGKMFVTK PLDREHRSSY
HLRAHAVDMN GNQVENPIDL YIFVIDMNDN RPEFKNQVYN GSVDEGSKPG TYVMHVSAFD
GDDNTTANGM VRYRILSQMP HSPIPNMFTI NSETGDIVTV APGLDREKVS QYTIIVQATD
MEGNLNFGLS NTATAIITVT DINDNPPMLT SRTFSGEVPE NRVDLAVANL TVIDADQPHS
PNWNAVYRII SGDPSGHFTI RTDPVSNDGL VTVMKRTDAE QQRVSIRSPP VSGRLSLSST
SSSSVRLRFN PGDDPPFLPR PLSRGMSPPA TASRFLSDDR YRDAITPPYS KLSDLADWLS
INRTNGQIVT TAMLDRESIY VKNNIYEATF LATDNGSPAA SGTGTLQIYL IDINDNPPAL
IPRESQICER VNKNVHGVNI TAADADTDPN AGPFVFELPN FPSSIRRNWT ISRISGDFAR
LGLRYQIYLE PGVYEVPVIV SDSGNPPLSN RSVIKVKVCP CDEHGDCTTL GAVAAAGLGT
GAIISILICI IILLTWCCCF VVWMKRREKE RHTKQLLIDP EDDVRDNILK YDEGGGEEDQ
DYDLSQLQQP DSLEHIISKP PGVRRVDERP VIPESQYPIR PVVPHPGDIG DFIHEGLRAA
DNDPTAPPYD SLLVFDYEGS GSTAGSVSSL NSSSTGDQDY DYLNDWGPRF KKLADMYGGG
ED
//