ID G3PQR3_GASAC Unreviewed; 1462 AA.
AC G3PQR3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Calmodulin regulated spectrin-associated protein family, member 2b {ECO:0000313|Ensembl:ENSGACP00000019948.1};
GN Name=CAMSAP2 {ECO:0000313|Ensembl:ENSGACP00000019948.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000019948.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000019948.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000019948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- DOMAIN: The CKK domain binds microtubules. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
CC -!- SIMILARITY: Belongs to the CAMSAP1 family. {ECO:0000256|PROSITE-
CC ProRule:PRU00841}.
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DR STRING; 69293.ENSGACP00000019948; -.
DR Ensembl; ENSGACT00000019986.1; ENSGACP00000019948.1; ENSGACG00000015109.1.
DR eggNOG; KOG3654; Eukaryota.
DR GeneTree; ENSGT00950000182975; -.
DR InParanoid; G3PQR3; -.
DR OMA; YRGLYTW; -.
DR TreeFam; TF315529; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000015109; Expressed in diencephalon and 9 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0030507; F:spectrin binding; IEA:InterPro.
DR GO; GO:0031175; P:neuron projection development; IEA:InterPro.
DR Gene3D; 3.10.20.360; CKK domain; 1.
DR InterPro; IPR032940; CAMSAP.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR031372; CAMSAP_CC1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR038209; CKK_dom_sf.
DR InterPro; IPR014797; CKK_domain.
DR InterPro; IPR011033; PRC_barrel-like_sf.
DR PANTHER; PTHR21595:SF5; CALMODULIN-REGULATED SPECTRIN-ASSOCIATED PROTEIN 2-LIKE ISOFORM X1; 1.
DR PANTHER; PTHR21595; UNCHARACTERIZED; 1.
DR Pfam; PF17095; CAMSAP_CC1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF08683; CAMSAP_CKK; 1.
DR SMART; SM01051; CAMSAP_CKK; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50346; PRC-barrel domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS51508; CKK; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|PROSITE-
KW ProRule:PRU00841}; Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 234..345
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1325..1459
FT /note="CKK"
FT /evidence="ECO:0000259|PROSITE:PS51508"
FT REGION 511..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 739..769
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 511..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 814..828
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 914..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1020..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1285..1301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1462 AA; 162105 MW; 101FE41A19795EE9 CRC64;
MGDAAEDIIL RGMRRTFIVP SIKSFDHYDF TRAKISCSLT WLVAKAFGSD AVPEELAEPL
YRDQYNQEHL KPPVACLLQS AELYCRAGSL ILRSDAVKPL LGHNAVIQAL AQKGLYVTDQ
DRLVTERDLA STPIHMSSHL ALIDTLMMAY TVEMVSVERV MTCINRCSSA EPSHMDGHLQ
ELPYDTEDAI HTWINKVNEH LRDILVEEQK LREASPQESD ATTHKSPCKW YWRLVPARYR
KDHAQQMSAP SLPLVENLLK DNTDGCALTT LLHFYCPQAI RLEDICLKET MSLADSLYNL
QLVQEFCRDN LNHCCHFSLE DMLYAHASIK SNYLVFMAEL FWWFEVVKPS FVQPRVFDPD
GTVQVQNNLS MLLLAPIKQS YADGPDSPDN APAQVEKGDL IHAIRSYSVS ATGIMKRSAS
MSYVDGCVGT WPKEKRSSCR GISFEIPLVG DPTVLPGEAP ALGGMTRSAS SDGLGFKVHY
ASRGGMKRHL SLMPVNVNGQ GRHIAEEANR DFKQSSVNLP KSVPRYSNGV FPESNHHGNR
RSHISPSTPP SIEEALKIIH DTERPHASLG VGDGDNGFFL HGTEPPDPTD ASGAKGQGDE
QDEVDTGIHV RTEDIQSLDE DSSSLRDYSD IDPDCEAVTR SCPLPEQSVG DGSERGSPCP
SSAPTIQRSH PGSPASSSGG SGGGVVRMTS FAEQKFRKLE GRSSGGTTPE SSDLNVPYTQ
LPKSISFQPS PRDPSHLIAT EMIQLRMKLE EKRRAIEAQK KKVEAAFTRH RQRMGRTAFL
NVVRRKGITA PLSPSAAEAP SPEPPTASKE SNQGSMERAE RCKPDGAAPK SPCEEGGGQN
HMTLTRVSDT GTSPGEIDLT EYTRSIERMN TSLGFLQTEM QRLAQQQEKI MSMREEQQQS
WVIPPPAPSP HRQLRELRSS SVTGRGSGRG SVGSLSPILS SSGSPRPPNR SPAGIKRRPA
SFHARTPRTP RPNDLKVTPF SRMLNTQTSV DSLPRLRRFN PSQNQNSSFA YLGHDEGPLE
GQNQEAKDHR ENTKDKEDLL SAKEAAKEKE DERQKERTGE VQPASSSEVL SQPVSEIQRP
TGGRVREQPQ DRRHLVEVTL SGLKPPGGRP GGPETGGGEG DVEAGGDPLG KDQKMCCGFF
FKDDVKAEED MAAKKAFLLE KRLRREKETQ EKKQQQEVDH EQKREAARLK ADEDQQKKDQ
EKARREYIKQ EFMRRNQLKL MENVDEVTKP RSGSLKKKPR PKSIHRDVME SLTPPVRATG
FSVSSISLAS LNLADDDQPN NRKNNRPDSA EGFSSCPSTG SRNEEKDWEN DSTTSSTPSN
NEYTGPKLYK EPSAKSNKYI IQNALAHCCL AGKVNEGQKN KILDEMEKSE ANNFLLLFRD
AGCQFRSVYA YCPETEEITK LAGIGPKSIT VKMIEGLYKY NSDRKQFSLI PAKTMSASVD
AITIASHLWQ TKKQATPKKL HA
//
