ID G3PQU2_GASAC Unreviewed; 461 AA.
AC G3PQU2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Putative malate dehydrogenase 1B {ECO:0000256|ARBA:ARBA00039310};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000019977.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000019977.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000019977.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 2 family.
CC {ECO:0000256|ARBA:ARBA00009613}.
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DR AlphaFoldDB; G3PQU2; -.
DR STRING; 69293.ENSGACP00000019977; -.
DR Ensembl; ENSGACT00000020015.1; ENSGACP00000019977.1; ENSGACG00000015146.1.
DR eggNOG; KOG1496; Eukaryota.
DR GeneTree; ENSGT00530000063410; -.
DR InParanoid; G3PQU2; -.
DR OMA; FKITQHP; -.
DR TreeFam; TF329007; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000015146; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016615; F:malate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006108; P:malate metabolic process; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR010945; Malate_DH_type2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23382; MALATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23382:SF1; MALATE DEHYDROGENASE 1B-RELATED; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 292..460
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
SQ SEQUENCE 461 AA; 51760 MW; 3F96C8DF3888CAC1 CRC64;
MAKLVLAGKA DCPHYAKAEL LSDRLQRSLP DFRIHKISIL PHEWRKWLEA TCTRNGWKHE
RSPLVWRELV HQGGKGMLLG GFSDFVEHCQ DYYSITSDML TDSMLAVAAE NLETKMNIIA
EEQRCLNRIE PLHIWISSAL NPTCNFLIPN LLSAEVFPHV STISLHLLDL KGNEEGLRGL
RMETEDLALP LLHQVSIHTD LDQAFQGADV ILLLDEWWSD DGDGEEQKKN VKGMSDRYIE
YGQLIDTRAN KEVKVIVSAD SFANWRCSLL LEHACSIDSH QFITMATQLE NEAKAILATK
LKVRTSDIRN VIVWGNISGS FYIDLQWTKV FNYDGAIKGP AFFSQPALKL LHQRKWLETD
FQDMARRRRA EAASKSCRAA SMSAADGILA VLAAWNGGSD GVFSVGVLCQ GEYNLPDGIV
LSLPVNFTGG KLGVLSEATI GDELKEKLCF FARELMQEKE L
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