ID   G3PS01_GASAC            Unreviewed;      1151 AA.
AC   G3PS01;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000020387.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000020387.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000020387.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR   AlphaFoldDB; G3PS01; -.
DR   STRING; 69293.ENSGACP00000020387; -.
DR   Ensembl; ENSGACT00000020426.1; ENSGACP00000020387.1; ENSGACG00000015458.1.
DR   eggNOG; KOG1958; Eukaryota.
DR   GeneTree; ENSGT01030000234638; -.
DR   InParanoid; G3PS01; -.
DR   OMA; HPPRIAQ; -.
DR   TreeFam; TF313152; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000015458; Expressed in liver and 11 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10809; GH38N_AMII_GMII_SfManIII_like; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF70; ALPHA-MANNOSIDASE 2; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|RuleBase:RU361199};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          486..577
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1151 AA;  130550 MW;  DEDF413AEADF17AD CRC64;
     SKMKRKLFPL LVGGVFCVVV MSLYRMLEMM QGAELQHLEA PAGQDFYRLQ QQIDKLERLL
     SANNRLVVTL RDSLLHRQAP QGGGGAVNVS AGSAHSPADA PPGCRLAQGM KGRADGVQLL
     DVYNLLPFDN ADGGAWKQGF EISYRGNEWD EQPLEVLLVP HSHNDPGWLK TFENYYQDQT
     RHILNNMLIK LTEDSRRKMI WAEISYFSKW WNDIDEQKRE MVKRLVGAGQ LELVTGGWVM
     ADEANSHYFA LLDQLIEGHQ WIQRHLGVRP RSGWAVDPFG HSPSMAYLLK GAGLSNMVIQ
     RVHYAVKKHF AQQQTLEFLW RQSWDSSPRS DITCHMMPFY SYDVPHTCGP NPAVCCQFDF
     HRLPGGRAMC PWKKSPQPIT EQNVQERALL LLDQYRQKSR LFRSHVLLVP LGDDFRFVEA
     SEWDAQSGNY QKLFDYFDQH PELHVKARFG TLSDYFEALH RRLDAMGTAL PALRGDFFTY
     ADRDDHYWSG YFTSRPFYKR LDRTLEATLR ATEILFSLAL AEMRRFRGDG LLVADFPVRE
     HFRRLTAGRR SLALFQHHDG ITGTSRDPVV VDYGTRLFHS IMNLRQVLQS SAHWLLLLDK
     SQYYHNQSKP FMQLDDVISA HNALPLKTPL ALSNEPRSLI IFNPTEQLRS SVISVVVDSP
     DADVVDATTG QPMAAQISAV WAEPTQASTE QFQLDFVAEL PPLSLVVYHV TKASFGSAHR
     ARYTFHRRGN PPAVQSEHFQ VSGLERPEAD APLSLSNKHI SIWSSPETGL LQKLRLLPGP
     VREVQVQFLW YGTQRNQDKS GAYLFLPGEE GAQLYSSSEP PLVRVSRGPV FSDITSCFRH
     FTHTVRLYHL DGHAGRSLEI SNMVDIRSEF NRELVMRLVS DVANGNRFYS DLNGFQMQQR
     RTLQKLPLQA NFYPMTSAAF LQDATSRMSL LSAQSQAVAS LRPGELEVVL DRRLQQDDNR
     GLGQGVTDNK LTASLYHLLL EDRRGGAEEV GGASVEHMSL LAHLTSLSLN HLPITMVAPS
     DSQVPKLRPF LPLRSSLPCD VHLLNLRTLE DSQDKQESDS PSQEVALLLH RKGFDCSSAP
     QAPLQCTWSA QEEVDLDRLF SPLRFHSVRR SGLTLLREDD QPESARQPAP PHVARLRPME
     ISAFRVELAW T
//