ID G3PSW6_GASAC Unreviewed; 920 AA.
AC G3PSW6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=HFM1 {ECO:0000313|Ensembl:ENSGACP00000020702.2};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000020702.2, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000020702.2, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000020702.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR AlphaFoldDB; G3PSW6; -.
DR STRING; 69293.ENSGACP00000020702; -.
DR Ensembl; ENSGACT00000020741.2; ENSGACP00000020702.2; ENSGACG00000015686.2.
DR eggNOG; KOG0952; Eukaryota.
DR GeneTree; ENSGT00550000074822; -.
DR InParanoid; G3PSW6; -.
DR OMA; HCKNKHT; -.
DR TreeFam; TF328936; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000015686; Expressed in testis.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 22..209
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 250..435
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 793..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 103470 MW; 126D9AC2ADA987E1 CRC64;
AKFRSVFKEF PFFNYVQSKA LDDVLYTSKN FVACAPTGSG KTVLFELAII CLLMESSEPW
RDVKAVYMAP IKALCSQCFE SWKKKFGPLG LTCKELTGDT EIDDFFEIQD SHIILTTPEK
WDSMTRKWKD NCMLQLVRLF LIDEVHVVKD ATRGATLEVV VSRMKAVHAY RTAQNPETGL
SMRFVAVSAT IPNTSDIADW LSDDSGPATY LDMDESYRPV KLRKVVLGFP PTPNQTEFKF
DLLLNYKMAN IIQTYSDQKP ALVFCSTRKG VQQAATVLAK DARFMMSIEH KQRLTKYANS
ILDSKLRDLV VLGVGYHHAG VDLSDRKLIE EAFTQGDLPV LFTTRTLAMG VNLPAHLVVI
KSTMQYVSGS CEEYSEADLL QMIGRAGRPQ FDTSATAVIM TKTQTKDKYM KLMNGVETIE
SSLHSHLVEH LNAEIVLQTI RDVNMALDWI RSTFLYIRAL KNPTHYGFPA NLDRYGIEAK
LQELCLKNLN SLSSIGLIDM DEEINIKPTE GGRLMARYCV AFDTMTQFSK ASGTESLSDL
VELVSKSREF SDIQLRMNEK RSLNTFNRDK NRITIRFPIQ GKIKTSQMKV NCLIQAQLGS
ISIQEFGLTQ DTAKIFRNGM RISRCMSTLS TAMVNAGLTT FSRIEQINAR ELELIVNRHP
PFGNQIKESA TNLPKYEVTL EQLPRYSCAT AEIVLKVNLK NQAQLLSRRT APDDHYISLI
IGNSDNAVVF LQKLTDLVLL KCGTWSKKIE VAKASKGEEI SVNLISSQYV GLDIQQRFNV
YYSGARRFGN EILSNTPFDP TGQRPQHAAL KPHSTDQAAG HRENATSATE QGTAPQCNHY
CKNKDLCGHD CCKVGVAVAK KRPANQESSF SSYLKDLRNR CDTLSQTPVK RLKIKMSDYS
VPVDIQEFAY KPKERLPTAS
//
