ID G3PTL1_GASAC Unreviewed; 299 AA.
AC G3PTL1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein {ECO:0000256|ARBA:ARBA00015474};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000020947.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000020947.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000020947.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3PTL1; -.
DR STRING; 69293.ENSGACP00000020947; -.
DR Ensembl; ENSGACT00000020987.1; ENSGACP00000020947.1; ENSGACG00000015872.1.
DR eggNOG; ENOG502RXWE; Eukaryota.
DR GeneTree; ENSGT00390000002016; -.
DR InParanoid; G3PTL1; -.
DR OMA; QPCSRFL; -.
DR TreeFam; TF331882; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000015872; Expressed in intestinal epithelial cell and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.30.70.680; TRADD, N-terminal domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR035712; TRADD.
DR InterPro; IPR009095; TRADD_N.
DR InterPro; IPR036729; TRADD_N_sf.
DR PANTHER; PTHR14913; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR14913:SF0; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF09034; TRADD_N; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF55044; TRADD, N-terminal domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 211..284
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 299 AA; 33348 MW; 6B6D7A188F53D083 CRC64;
MAYKTVDGGP WTGCAVLFLR SLCPGVNLLS LFKDREQGKF VVFKVIKLTL TDSAGGLGGH
EILKIHDADP FLGVEVKFND MLACRQFLES YSSGAVRQSL SQHAGRLLTL PQEFTVETQL
KASAHILDLC LDQLELCLQH VHLSQPERLR DEEIEHLEKQ LEIQARGSEP QPDPPTQEEC
PVPSHCFKFQ NKPTEDRMLT GGDVQSFSSG VGRQWKHVGR ALAKSCQALK GPAIDNLAYE
YEREGLYEQA YQLLSRFIQA EGRAAKLSRL VKALEDCKLT SLAERNDLLS LFNGHTVLS
//
