ID   G3PVB8_GASAC            Unreviewed;       119 AA.
AC   G3PVB8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=Polyadenylate-binding protein-interacting protein 2 {ECO:0000256|ARBA:ARBA00040702};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021555.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000021555.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000021555.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Acts as a repressor in the regulation of translation
CC       initiation of poly(A)-containing mRNAs. Its inhibitory activity on
CC       translation is mediated via its action on PABPC1. Displaces the
CC       interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for
CC       binding to PABPC1. Its association with PABPC1 results in disruption of
CC       the cytoplasmic poly(A) RNP structure organization.
CC       {ECO:0000256|ARBA:ARBA00037448}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the PAIP2 family.
CC       {ECO:0000256|ARBA:ARBA00006858}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; G3PVB8; -.
DR   STRING; 69293.ENSGACP00000021555; -.
DR   Ensembl; ENSGACT00000021596.1; ENSGACP00000021555.1; ENSGACG00000016329.1.
DR   eggNOG; ENOG502RZKX; Eukaryota.
DR   GeneTree; ENSGT00390000017284; -.
DR   InParanoid; G3PVB8; -.
DR   OMA; QEFVPGW; -.
DR   TreeFam; TF326855; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000016329; Expressed in muscle tissue and 12 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IEA:InterPro.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IEA:InterPro.
DR   InterPro; IPR009818; Ataxin-2_C.
DR   InterPro; IPR040396; PAIP2-like.
DR   PANTHER; PTHR13154; POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR13154:SF2; POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2; 1.
DR   Pfam; PF07145; PAM2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          99..113
FT                   /note="Ataxin-2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07145"
FT   REGION          88..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   119 AA;  14294 MW;  2DF52085686361BD CRC64;
     MRDPRLSRET TTINTELVLN RVPEDDPFAE YMWMENEEEF NRQVEEELWE EEFMERCFQE
     MLEEEEQWEW FIPSRDLPQE VQELVVSSGG VETEDMGNMK SSLNPNAKEF TPGIQKHVM
//