ID G3PVX7_GASAC Unreviewed; 858 AA.
AC G3PVX7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=HECT domain containing 3 {ECO:0000313|Ensembl:ENSGACP00000021766.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021766.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000021766.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000021766.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3PVX7; -.
DR STRING; 69293.ENSGACP00000021766; -.
DR Ensembl; ENSGACT00000021807.1; ENSGACP00000021766.1; ENSGACG00000016471.1.
DR eggNOG; KOG0939; Eukaryota.
DR GeneTree; ENSGT00940000159923; -.
DR InParanoid; G3PVX7; -.
DR OMA; PAWDYTL; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000016471; Expressed in intestinal epithelial cell and 13 other cell types or tissues.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd08666; APC10-HECTD3; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 212..394
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 528..854
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 820
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 858 AA; 97455 MW; E3C833B4AF6C2487 CRC64;
MSLGDNPHLL LGRVRFLNRC IECFKRGEAL PECLCYVPKE VCYKICKDSS SASSASTGAS
AGGSTAGKTL VAVFESPHQA PQVKRCAKYN IEPRKGTCVR TTGEEYCNSQ GLWVKINKEQ
LEEHRPAQEL EEGWILVCKH KEGGDRLVPV ESPETTSRQQ QLFGYDHKPC NRWEQVVSVE
NALYMGSKPQ IAECDEAAVQ KLRYVPPTWA YECDEDLVHY FYDHIGKEDE NLGSVKECVT
SIDVSSCSED PTGGASCLTD GDTETYWESD GMQGQHWIRL HMKRGTVVNK LILTVDSTDD
NYMPKRVTVY GGEGDNLKKL SDVTLDDNLI GEVCVLEDMT SHLPMIEVRI EECRDEGIDV
RIRGLKIKLS CERDLGLNAD VFQSSNLVRY PRLQGNTPEV LYRRALVIQR FICLLDTVLQ
HLVPAWDYSL GTFNHIKSIK QFLLLSKRRS ALITQCLKDS ETSKPNFMPR LYINRRLAME
HRDNPSLDSS CKNTVFNQVY EGLKPSDKFE KTLDYRWPAR YDQWWECKFI AEGIIDQGGG
FRDSLADMSE ELCPSSAECP MPLPFFSRTS NQGSLEARDY YVPNPSCKEF HKYEWIGQLM
GAALRGKDFL VLALPGLVWK QLTGEAVSWN KDFPAVDSVL VNLLEAMENL DQETFEFRFG
EELVYTTLLS DGQMVELIPG GSNVAVRYED RSEFIRLVQK ARLEESKQQI AAMQAGLLKV
VPQAVLDLLT WQEVEKKVCG DPEITVEALK RLKPARYEDR EQSDVRVQYL WEALTSFTNE
DRSRFLRFVT GRSRLPAPIY VFPDKQGSET TDALPRSSTC SSTLYLPNYP SAKVCEEKLR
YAAYNCVAID TDMSPWEE
//
