ID G3PW32_GASAC Unreviewed; 485 AA.
AC G3PW32;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Fascin {ECO:0000256|PIRNR:PIRNR005682};
GN Name=FSCN1 {ECO:0000313|Ensembl:ENSGACP00000021821.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021821.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000021821.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000021821.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245, ECO:0000256|PIRNR:PIRNR005682}.
CC -!- SIMILARITY: Belongs to the fascin family.
CC {ECO:0000256|ARBA:ARBA00007415, ECO:0000256|PIRNR:PIRNR005682}.
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DR STRING; 69293.ENSGACP00000021819; -.
DR Ensembl; ENSGACT00000021860.1; ENSGACP00000021819.1; ENSGACG00000016520.1.
DR Ensembl; ENSGACT00000021862.1; ENSGACP00000021821.1; ENSGACG00000016520.1.
DR eggNOG; ENOG502QPRX; Eukaryota.
DR GeneTree; ENSGT00950000183157; -.
DR OMA; CTAKAPG; -.
DR TreeFam; TF323992; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000016520; Expressed in telencephalon and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR CDD; cd00257; Fascin; 4.
DR Gene3D; 2.80.10.50; -; 4.
DR InterPro; IPR008999; Actin-crosslinking.
DR InterPro; IPR010431; Fascin.
DR InterPro; IPR022768; Fascin-domain.
DR InterPro; IPR024703; Fascin_metazoans.
DR PANTHER; PTHR10551; FASCIN; 1.
DR PANTHER; PTHR10551:SF23; FASCIN; 1.
DR Pfam; PF06268; Fascin; 4.
DR PIRSF; PIRSF005682; Fascin; 1.
DR SUPFAM; SSF50405; Actin-crosslinking proteins; 4.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005682};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR005682};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 16..127
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 136..246
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 259..367
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
FT DOMAIN 382..485
FT /note="Fascin"
FT /evidence="ECO:0000259|Pfam:PF06268"
SQ SEQUENCE 485 AA; 53282 MW; AFB50A984937911D CRC64;
LEGGKIPLGL INVEGKYLTA ETFGFKINAS AGSLKKKQTW TLEQSGEDGS AAFLRSHLGR
YLAADKDGNV TADSEARGGR DCRFVVTAHE DGRWSLQSEP HGRYLCGSED RITCFAQAAA
PAVRWSVHLA VHPQVNLYSL ARKRFAHLSE REVSIDRDVP WGVDSLVTLV YRDQRYHLGT
SDNRFLRNDG GLAARTEART GYVLEFRSVK VAFRDCDGRY LAPSGPTGTM KSGKSTRAGK
DELFGLERSH AQVVLTARNE RNVSTRQGID LSANQDEEGD QEVFQLEMSR EDRKCAFRTA
AGKYWTLTAS GGLQCTASTK SADSYFELEW RDGRVCVRAA NSKYVIAKRN GQLAATVDSA
GEAEQFLMKL INRPIIVLRG EHGFIGARKP GLATLDSNRA SYDVFQLEFH NGAYSLKDSQ
GKYWCVGDDA AVACGSDAPV QFLLEFCDLN KMAIRAPGGK YLKGDHAGGL KASADSLDGA
TRWEY
//
