ID G3PWE3_GASAC Unreviewed; 1613 AA.
AC G3PWE3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Pregnancy-associated plasma protein A, pappalysin 1a {ECO:0000313|Ensembl:ENSGACP00000021932.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021932.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000021932.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000021932.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR STRING; 69293.ENSGACP00000021932; -.
DR MEROPS; M43.004; -.
DR Ensembl; ENSGACT00000021973.1; ENSGACP00000021932.1; ENSGACG00000016615.1.
DR eggNOG; ENOG502QQ7Z; Eukaryota.
DR GeneTree; ENSGT00940000156654; -.
DR InParanoid; G3PWE3; -.
DR OMA; KQVVCEP; -.
DR TreeFam; TF331636; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR CDD; cd00033; CCP; 3.
DR CDD; cd04275; ZnMc_pappalysin_like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF2; PAPPALYSIN-1; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 2.
DR SMART; SM00032; CCP; 3.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50923; SUSHI; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1613
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003450183"
FT DOMAIN 1272..1333
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1399..1459
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 708..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1401..1444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1613 AA; 180330 MW; 22FBCE8190B2FEB2 CRC64;
MKLWTSPWVS CLVILLLCFG SECGTVRRKG RSKRELVRIR EAKATIPGAC ATRLPRGKRS
LPGLERRVLR QRRRSSLAEE NSPDRGKAVY FTGRGDQLRL KPGVEIPRGN FTLEMWIKPE
GGQRSPTVIA GLYDKCFYAS SDRGWAAWHQ ALVNMGTVTL DFFFSLKTDR AAQTTPTLAI
YPTKWAHVAV TYDGVYMKLF STAPKWCQSG AIGHLTKKCK VLMIGGNALN HNYRGEVERV
CLWRQARGQR QIVRHMQGHE DTQDLPQLVI RETFEYPGRK WLTVKDGSFP KPDLGGGGRL
LDTTLDPPTC GQTVCDNVEV IKNYNHLWTF RRPKKVRYRV INVWDDARMK PTVSDHQISL
QHQQLNDAFS PYNITWELSI YNVTNSSLRN RLILANCDIS KVGDDVCDPE CNHPLTGFDA
GDCMSGFRSR CPEHKQGNGV CDPECNWENF FYDLGDCCNP NVTDVTKTCF NRSSPHKAYL
DVKELKEILR LNGSTHLNVF FANSSDEDLA GVATWPWDKE ALTHLGGIVL NPSFYGTFGH
TDTMVHEIGH SLGLYHVFRG ISEIESCNDA CLETDPSMET GDLCADTNPT PKYKGCHDPE
PGNETCGCRH FTHTPFNNYM SYADDACTDS FTLNQVARMH CYLDLIYQTW QPASKPPPVP
MSPQVVEQHH NSITLEWFPP ISGHFYEREV GSVCDKCTEG GVLLQYASNS SSPRPCAPSG
HWSPREAEGP PDVEQPCEPS VRTWSPNAGI EQGVVGLSEC PLQGCMLQLE FTYPLVPDSL
TVWVTFFSPE ETALPAIHNI LLLTVGGGTI SLGPSNVFCD TPLTLKLDTK EEVYGVQFFT
MEQHLEIDAT LLASKPGNKL CKDCQPLRYR LLRQPHFTHA QYGLMLNEPT RRYTDRDVAP
HVVYTYQVQT ISARSESEPS PPLIHELGAP YCGDGRIQSS KGEECDDMNS MNGDGCSSQC
KKEAFFNCVE EPSLCYYYDG DGVCEDFEQE TGVRDCGLYT PNGFLDQWAS AVEVSHEEKL
YCSGDVTAGY PAVTKTCQSK VFDLSDGVSQ YAWFPCREAH KSTWGYPNYW LKAHFSHPMV
AAAVIIHLAA DGTGYLDQTQ CNITVQLVDT KEGIHSLGEW RLSCRTNPLV IPVSHDLSVA
FYHTKAILVM FASRLVAISG VGLRSFQSFD PITISGCQSN EIYNPTGQSC VYYSREGIHS
HKLLSRMALL SALALARHFY KGDRCSLPCK KKQGLARQAS REDDIMNIQS ATAVTITCAN
GKWNKQVSCE PVDCGLPDKY HVHPALFDFP EGTTYGKKST FQCREPAQLV GTNNSLTCLE
DGLWSFPEAL CELRCPAPPV VPNAVLQTKR CNDTGLKVGT LCKYNCRPGY HVSNKPKRRA
FKRQCTEDGS WLEGACEPVT CDSPPPIFHG SYRCTDGFRY DSVCKLNCSD AAESQGAGSN
AIRCKKDGTW TGSFRLCPHS KGQCSLPQNL HHSLQYSCKQ GHGIEECELT CREGNNDVVI
LPSNMTLENV LIEHWRNPHR VKSIVCTMGL KWYPHPELLH CIKGCEPFMG DNYCDSVNNR
AFCNYDGGDC CQSTVKTTKV IPFPMSCDIR DECSCRDLNA FENRKDEHLH SLG
//
