ID G3PXB2_GASAC Unreviewed; 3243 AA.
AC G3PXB2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000022251.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000022251.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000022251.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 69293.ENSGACP00000022251; -.
DR Ensembl; ENSGACT00000022293.1; ENSGACP00000022251.1; ENSGACG00000016846.1.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000164636; -.
DR InParanoid; G3PXB2; -.
DR OMA; FSFAETQ; -.
DR TreeFam; TF316403; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000016846; Expressed in intestinal epithelial cell and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 26.
DR Gene3D; 2.60.40.60; Cadherins; 27.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF329; DACHSOUS CADHERIN-RELATED 2; 1.
DR Pfam; PF00028; Cadherin; 24.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 27.
DR SUPFAM; SSF49313; Cadherin-like; 27.
DR PROSITE; PS00232; CADHERIN_1; 12.
DR PROSITE; PS50268; CADHERIN_2; 27.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2885..2907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 34..99
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 100..211
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 212..318
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 323..429
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 430..535
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 536..643
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 644..748
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 749..851
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 852..945
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 958..1063
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1064..1166
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1171..1270
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1288..1388
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1389..1503
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1503..1607
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1608..1710
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1711..1814
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1815..1920
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1921..2026
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2022..2124
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2125..2229
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2229..2329
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2330..2434
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2435..2550
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2551..2658
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2666..2771
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2772..2882
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 2954..2980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2959..2973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3243 AA; 350402 MW; E0C9A1852CBC1991 CRC64;
GQVFNLTLSV KEGLPAETIV GDLSAGLSGP STGFFISESR DSYVFRDLEI DADTGIISTA
VVLDRESRDK YEFVAATLAG EVIRVKLEVE DVNDHSPQFP SEAVDLEISE QSPPGSRFHL
EGARDEDEAE FGTQGYRITE RGVGELFRLE YRSGSEDHPS LDLVLTSRLD RETLDFYSLA
IEAFDGGVPA RTGTLQVNVR VLDENDNPPA FDRSEYHASL PEGAAVASAV CQVTATDLDL
GENGRITYEI NRRQSDPDEV FSINETSGLV YLNKPLDYET QAFHELVVGA RDNGAQPESS
SAFVGVKVLN VNDNSPAVSV LFLSETGEAV VSEAAAVGDY VARISVSDPD FKEERVTVTL
EEDGDDGKFI LTQTDDYLYA LCVNAQLDRE ERDLFELKVR ASDSGSPPLS SETVLLLRVT
DANDCRPAFE RDAYVVRVPE DAPRGSALIQ VRARDADEEG VNSEVRYSIP GFDRDGPVSV
DPESGWVTTA AALDREARAE VRFLVVAADG GEPALSSTAT VTVLVEDVND NEPVFQRQLY
NVSIPEHGDV GSCFLQVVAT DADGPEFSEL LYSLSDGFDA EDKHPLFSVH PRTGQLCVSR
DIDRDSGQTV HDVLIRAEDP GGLSAQTHVR VEVEDLNDNA PVFNPGEYAA SISGHAQPGT
EILNVVASDR DSGRFGRVTY HVLPGDVSGL FSLDATTGTL LLTSTLTHLG AASVKLSVTA
RDGEGVNAAR PAEVTINVLR SAQAPAVFKR SRYTFTVPED APPGTPVGTV EAVNPAADSE
SATYRISSGD PRGLFSVHPK SGLISTVDLL DRESQPYALL ILQSHSDASP VCGTTQVNVT
VADVNDNAPA FPKPGDAVAV SQNTRPGTVL FIARARDRDS GANGEVRYHL KSTANGTFVV
DRRLGTVTLN QSLQGGHQQR YNLEIVAEDG GEPPLSSTLT LAVSVELAAA AEDGLAFETL
VYQVEIGEGY RKDARVIQVR AHRGRGAHGS NSGITYTLEA EAGFPPAPFR VHPNTGWLFL
SRGLDFETEP EFRFRVEASL ANATASAAVL VLVLDVNDNP PAFGSEVYHF TVPEGSSPRG
LVGTVKAVDE DSGKNAQLSY ILLTDGKFFR INSKTGEIIN WVALDREQHS QHSLKVMVTD
NGRPRLNATA AVHILVTDLN DNTPQFTHLP ASKELSVQIW AGLPAGSLVT NMFAKDLDAG
ENGTVTFSLV AADSQVEGFG PFEIDGESGD IRTTEPFAHQ NSGSFYAVKV TARDGGVPPL
EDTALIHVQV FSFLMLSLVQ VDGLDSERQM MRRFTVREDA EPATVIGSAA VSSEGRFRYS
ISEGDGSVHF GIDGSSGDIY VNQPLDYESA AQYRLTVRAE DEGPSAGANA SLLVAVAVED
VNDHTPWFPD KLVTFGLRED AAVGSLAFAF RARDGDGTFP NSALRYSLAL DSQLGRSPSR
FPFHVDPGTG RLTVTAPLDR ETNPGFAFTV TATDRAERTE ERRRSSVTAQ VFLLDVNDNR
PVFVSVDTVQ VMEDAEVGSL LHRFVSIDGD LGENGVVSYV VTAGNKRGFF TLEEKSGLLF
LSSPLDYETE RFHRLTVRAV DHGLPPLSST QTLTVEVEDV NDRRPVFSES IYNASVAENR
DPGEPVIRVS ATDDDSDGEG GMCLLPGAGY ELFSIDPHSG LITTTSQLDR EQQHHFTLRV
QARDSSTRPL SGTATVLCAV LDDNDNPPEF MQPSFQISLP ENLPPGGVHT AQASDPDSGE
NGTIHYSILG DDHRGRFTIN SRTGAVSTTR VLDREEMQNY TLAIQACDYG ATQLCSSTRL
QLLLLDQNDN VPSFTRKSYH ASVSEGLPAG AEVLRVHAFD PDEGPNGDLT YSLTEDSSQG
AFSVDAFTGV IRTTRSLDRE ARAQYTLRAV AVDGCSQGPL SSVASLTVQV EDVNDNAPVC
EQNPVNAWVS AGTPPNQIVA TVAATDGDQG DNGTVQFALS DEENLFEING ESGEISLRRR
VRAGFSGRNL QVVVSDKGRP ALSATCLVVI HLKGEHEGLQ FTDKVYNATI KENSRAGAWI
AIVEASDQTN IRQRITYTIF SGNENHVFSI NRHTGEIRVQ KDNSLDYEAS PQIQLVVLAD
NGLQTAHCRV SVALLDVNDN APVFEHSGYR TAVWEGQVHN TYIMQVFASD ADSGLNGQIE
YSIVSGNPNQ AFVLDSVRGI LATRVLLDRE ITPSYKLVLQ AADRGNPPLS STTTLRVQVV
DVNDNSPAVP PMEPVVVAEN LPAGYKVTQV TANDVDLSST ITYSFSDNSS TDFPFAIDPY
TGVVTLTRAL DYEARTEYTL TVWASDSLHQ TTGEVKVEVL DVNDNAPVFT EVSYQVELSE
LVSEDTLVLS VSATDSDSGL NGKINYRLLS SPLQGFYIVP DNGSVFTNKP LKAITNGNLI
HLLVEARDEG EPMQSTVASV DVLIVDTNDH TPLFHQDIYT LTVPEDTPTD TTLLTLSAED
RDWSPENTHL DYGIIGGNEE RRFCLEVKMV QVENQMKNVG KLVLCNPLDR ETTESYALAV
RVSDRGTPPL NSSAVVTVTV TDCNDNAPVF SSTGYHAQVS ENSHVGARLV QVSARDPDLG
TNGLLRYDII SGNGKGHLKL NRQSGLLVVN HSLDYEEDPK YTLTIRATDG VESSEQRKVA
FTVVFITVLD ENDNTPYFMF PTVNCSVPEN LPAFTHTCSV HAVDNDSGPY GQLSYSIVSS
CFTDYGSGSP EKKEGFAIDP LTGDIHTRQT FDYERESEYC FVVEARDKGN KAATVRVTVS
IKGVDEFSPV FTQKQYHFLL SESTGPGEVV GYVMAMDHDG GVDGLVEYSL VRSSPFFSIN
KTIGAIFVSG PVYRRRGSQA SEDLVELVVS AASPRSTSRT TACLVLIDIS SSAEALTGVP
LDAHMLSLSV SLIMFLLMLL VFVGSLLKYK MKEAAIKKAA AVAANPDHET GSFGRAGSQS
AISLQEMKPP GVVVAETDGS TPCSPSDSSG RGSAEGETAE DQEIKWINQY PCRNRDDQVG
ELADSALPRD NISCHSADDV SEQMSSAEKR LVSAMASTES LHHFKEEGGG EGLLPAILRV
RDLEENMRTY GYAPLSEAHA SADSLSSLLC LEEQTHGSYS WDYILDWEPR FQPLASVFTD
LGMLPDEELQ GGREDLAAEA SCLMYPPPLI TGVAHPGIRT VHPRKPGRMP SLRRKPSYPK
YAYSPLGRNT GLTPSAMTPT FAPSLSSLTV RTPNASPVVS DTGVGGIRLD SGPLTASLLE
AEI
//
