ID G3PXL6_GASAC Unreviewed; 643 AA.
AC G3PXL6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Fermitin family member 3b {ECO:0000313|Ensembl:ENSGACP00000022355.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000022355.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000022355.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000022355.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the kindlin family.
CC {ECO:0000256|ARBA:ARBA00008052}.
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DR AlphaFoldDB; G3PXL6; -.
DR Ensembl; ENSGACT00000022397.1; ENSGACP00000022355.1; ENSGACG00000016924.1.
DR GeneTree; ENSGT00390000013444; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000016924; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd13205; FERM_C_fermitin; 1.
DR CDD; cd17185; FERM_F1_KIND3; 1.
DR CDD; cd01237; PH_fermitin; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037837; PH_Kindlin/fermitin.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF1; FERMITIN FAMILY HOMOLOG 3; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 343..439
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 643 AA; 73542 MW; 2E32605C1A2442E1 CRC64;
MASWDLAVTV EDLGSDAPAV TLSVASDLHV GGVILKLVEK TQIKRDWSDH AIWWEQKQQW
LLRTAWTLEK YGIHADARLL FMPQHKPLKL GLPNGKTLRL KACFSRPVFQ TVMGICKILD
IRHPEELSLL RPIEEKKKKK DKDSAEEIYD LTEVPLSSAS RPLLYDGMPA HFADSPEMEA
VYKMLSVTQP PPAPEVIAKQ YRPASVVDKA HINGRWLDSS RCLMQQGIQE NDRVWLRFKY
FSFYDMDPKY DVVRLTQLYE QARWAILLED IDCTEEEMML FGALQYHISK VSQSEPQMVS
SNAAMDDLDS ALQSLEVKLE GESSSASDML ENLTAPDLND YLKIFRPKRL TLKGYKQYWF
KFQDTSISYF KSKEESIGEP IQQINLKGCE VAPDVNVTAQ KFLIRLLIPA PEGMNEVYLR
CENEEQYAQW MAGCRLASKG KTLADSSFQN EIQSIRSFLA MQKKSSHGNA PTNDESINTH
SLVSPRYHKK YKAKQLTPRI LDAYQNVAQL SLTDAVMRFL QIWQALPDFG LSYVVVRFKG
SRKDEVLGIA PNRLIRIDLA VGDVVKTWRY NNMKQWNVNW DIRQMAIEFE GNINIAFGCV
TADCKIVHEF IGGYIFMSTR SRAKSDTLNE ELFHKLTGGH EAL
//
