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Database: UniProt
Entry: G3PXS7_GASAC
LinkDB: G3PXS7_GASAC
Original site: G3PXS7_GASAC 
ID   G3PXS7_GASAC            Unreviewed;       418 AA.
AC   G3PXS7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-NOV-2023, entry version 58.
DE   RecName: Full=Transforming growth factor beta {ECO:0000256|PIRNR:PIRNR001787};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000022416.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000022416.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000022416.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Precursor of the Latency-associated peptide (LAP) and
CC       Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute
CC       the regulatory and active subunit of TGF-beta-2, respectively.
CC       {ECO:0000256|ARBA:ARBA00034081}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR001787}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR001787,
CC       ECO:0000256|RuleBase:RU000354}.
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DR   AlphaFoldDB; G3PXS7; -.
DR   STRING; 69293.ENSGACP00000022416; -.
DR   Ensembl; ENSGACT00000022458.1; ENSGACP00000022416.1; ENSGACG00000016971.1.
DR   eggNOG; KOG3900; Eukaryota.
DR   GeneTree; ENSGT00940000166208; -.
DR   InParanoid; G3PXS7; -.
DR   OMA; WSANNHY; -.
DR   TreeFam; TF318514; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000016971; Expressed in heart.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR   GO; GO:0009790; P:embryo development; IEA:UniProt.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-UniRule.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   GO; GO:0009888; P:tissue development; IEA:UniProt.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR016319; TGF-beta.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR003940; TGFb2.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   PANTHER; PTHR11848:SF249; TRANSFORMING GROWTH FACTOR BETA; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   PIRSF; PIRSF001787; TGF-beta; 1.
DR   PRINTS; PR01423; TGFBETA.
DR   PRINTS; PR01425; TGFBETA2.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR001787-1};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|PIRNR:PIRNR001787};
KW   Mitogen {ECO:0000256|ARBA:ARBA00023246, ECO:0000256|PIRNR:PIRNR001787};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR001787};
KW   Signal {ECO:0000256|PIRNR:PIRNR001787}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT   CHAIN           22..418
FT                   /note="Transforming growth factor beta"
FT                   /evidence="ECO:0000256|PIRNR:PIRNR001787"
FT                   /id="PRO_5016196938"
FT   DOMAIN          302..418
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
FT   DISULFID        314..323
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT   DISULFID        322..385
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT   DISULFID        351..416
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT   DISULFID        355..418
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
FT   DISULFID        384
FT                   /note="Interchain"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001787-1"
SQ   SEQUENCE   418 AA;  47314 MW;  0FF680801E4C5C24 CRC64;
     MWLPRVALLL LRFSGVLLVE GFNTCHSINL DAQKSRRIEA VRGQILSKLR IRSPPGKDAA
     PPPGLVPAEV MLLYNSTREL LKERARLAES ACERESSEED YYAKEVQRID MLPPRTDTNA
     VQPATPDPHY RVVHFDVSGV DLTNSTLFKA EFRIFRAPNP QARASEQRVE LYQQLLKPDE
     ESTSTQRYID SRTVQPKEKG SWISVDVTET IKDWVSDPEN NLGMKLGVHC PCCTFVPSTN
     NIVPNKSEEL EALFAGLDDE QLRQMRKPGQ VKGQADFSTK TPHLILTVLP SDRADDPARK
     NRKKRAAATD TTTCSRGSDQ GCCLRSLYID FRRDLNWKWI HEPKGYKANF CAGNCPYIWS
     ANNHYNMILP LYNKLNPEAS ASPCCVPQDL EPLTIMYFIG RTPRVEQLSN MVVKSCKC
//
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