ID   G3PY19_GASAC            Unreviewed;       862 AA.
AC   G3PY19;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Prominin 1 b {ECO:0000313|Ensembl:ENSGACP00000022508.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000022508.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000022508.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000022508.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC       {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the prominin family.
CC       {ECO:0000256|ARBA:ARBA00006058}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; G3PY19; -.
DR   STRING; 69293.ENSGACP00000022508; -.
DR   Ensembl; ENSGACT00000022550.1; ENSGACP00000022508.1; ENSGACG00000017039.1.
DR   eggNOG; KOG4331; Eukaryota.
DR   GeneTree; ENSGT00530000063586; -.
DR   InParanoid; G3PY19; -.
DR   OMA; VYHLMMY; -.
DR   TreeFam; TF324631; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000017039; Expressed in camera-type eye and 1 other cell type or tissue.
DR   GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008795; Prominin.
DR   PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR   PANTHER; PTHR22730:SF8; PROMININ-1 ISOFORM X1; 1.
DR   Pfam; PF05478; Prominin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..862
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003450022"
FT   TRANSMEM        127..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        177..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        458..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        506..531
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        820..838
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          21..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   862 AA;  95580 MW;  FA707EEDDCBAE5AB CRC64;
     MLWRRWLVLL LCWGSTRGEQ QPAEERDGTA AEARVDPRRQ RSPPPVEPLD FGFVPAAVYD
     THAYYEPGAV GVLFHMVHAY LYVIQPNSFP KDLIVKVIQQ NMGGIKIDEW RKPENVVLLL
     QWIHYEAGFL ICATVGVTFL ILTPIVGFCF CVCRCCENCG GEMHQRQRKN VDCQRGFYTA
     SLIATSIFIV LGVLIAYAAN HNVSTQIKST RRLINTNIRD LKTFANNTPA QIDYLTAQYT
     TAKNKVLSDL DNIGPLLGGR INSQLEKEVV PSLDAALRMA GAMRETKEAL ENVGSSLEVL
     QEGTGKLLTS LSGERSSLSN TLSDPACTNG AVSHTCNAIR STLSQLGISA DFSTLPDVTR
     ALENINTVLK TDLSNIVQKG YSSFNDTPNL VKEQTKNIVS ALPRVKGMLD KIGIEINGFS
     KMFPVESSLV NFTIFLTQGQ KNIESYYPQV DQMDFYSRWI GCVAVLCMVV LVLAFNFLGL
     LCGTCGYDKQ ATPTTRGCLS NTGGNLLMAG VGFSFIFVWV LMGIVTALFV VGGNVEKMVC
     EPLANKTAGF KIIDTPFLVH PAKKNFLPGM LFQNPNIDLT LGSMYRDCYE NNGLYHSLQL
     ETMFNINTFL NRTVYNRDLA KVFESVQVDL QDITLLEQAG RDSLINFANS GVGHIDYEAY
     LAEVVNKGVT LVDLLTFSSD LEAQADQMPR GALENALKGH ASSIRQIHRE QVVPMEQAMS
     TLSQSIKQLQ RMSSDLPVKV TNILSAIDAA EYLITHNASY VVKQETKGYT QSLVGYFTQY
     TEWVKNSLTS EVAQCKPISN IVDSMEIVAC SFIVDSVNTF WFGLGGCCIL LIPSIIFSTK
     LAKYYRRMDT EDVFEDGQET WN
//