ID   G3PYE2_GASAC            Unreviewed;       484 AA.
AC   G3PYE2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=V-type proton ATPase subunit H {ECO:0000256|PIRNR:PIRNR032184};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000022632.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000022632.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000022632.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase),
CC       a multisubunit enzyme composed of a peripheral complex (V1) that
CC       hydrolyzes ATP and a membrane integral complex (V0) that translocates
CC       protons. V-ATPase is responsible for acidifying and maintaining the pH
CC       of intracellular compartments. {ECO:0000256|PIRNR:PIRNR032184}.
CC   -!- SUBUNIT: V-ATPase is a heteromultimeric enzyme made up of two
CC       complexes: the ATP-hydrolytic V1 complex and the proton translocation
CC       V0 complex. {ECO:0000256|PIRNR:PIRNR032184}.
CC   -!- SIMILARITY: Belongs to the V-ATPase H subunit family.
CC       {ECO:0000256|ARBA:ARBA00008613, ECO:0000256|PIRNR:PIRNR032184}.
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DR   AlphaFoldDB; G3PYE2; -.
DR   STRING; 69293.ENSGACP00000022632; -.
DR   Ensembl; ENSGACT00000022675.1; ENSGACP00000022632.1; ENSGACG00000017118.1.
DR   eggNOG; KOG2759; Eukaryota.
DR   GeneTree; ENSGT00390000003289; -.
DR   InParanoid; G3PYE2; -.
DR   OMA; DMLQEDK; -.
DR   TreeFam; TF313488; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000017118; Expressed in telencephalon and 13 other cell types or tissues.
DR   GO; GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; IEA:UniProtKB-UniRule.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-UniRule.
DR   GO; GO:0060348; P:bone development; IEA:Ensembl.
DR   GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR   GO; GO:0048069; P:eye pigmentation; IEA:Ensembl.
DR   GO; GO:0061075; P:positive regulation of neural retina development; IEA:Ensembl.
DR   GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR   CDD; cd00256; VATPase_H; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 1.25.40.150; V-type ATPase, subunit H, C-terminal domain; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR004908; ATPase_V1-cplx_hsu.
DR   InterPro; IPR011987; ATPase_V1-cplx_hsu_C.
DR   InterPro; IPR038497; ATPase_V1-cplx_hsu_C_sf.
DR   PANTHER; PTHR10698; V-TYPE PROTON ATPASE SUBUNIT H; 1.
DR   PANTHER; PTHR10698:SF0; V-TYPE PROTON ATPASE SUBUNIT H; 1.
DR   Pfam; PF11698; V-ATPase_H_C; 1.
DR   Pfam; PF03224; V-ATPase_H_N; 1.
DR   PIRSF; PIRSF032184; ATPase_V1_H; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|PIRNR:PIRNR032184};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|PIRNR:PIRNR032184};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transport {ECO:0000256|PIRNR:PIRNR032184}.
FT   DOMAIN          347..462
FT                   /note="ATPase V1 complex subunit H C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF11698"
SQ   SEQUENCE   484 AA;  55368 MW;  933F39725F06E9C4 CRC64;
     MDIRGAVDAA VPTNIIAAKA AEVRANQVNW QSYLQSQMIS AEDCEFIKKF EVANSEEKQV
     ILTNEGHQCA KTFLSLMAHI SKEQTVQYIL TLIDDTLQEN HQRVSIFFDY AKKIKNTAWS
     YFLPMLNRQD LFTVHMAARI IAKLAAWGRD LMEGSDLSYY FNWIKSQLSS QNLHGTGPET
     CTGAGTISPS ESSQYVQCVA GCLQLMLRLN EYRFAWVEAD GVNCITAVLS NKCGFQLQYQ
     MVFCVWLLAF SPQLCEQLRS YNVVPALSDI LQESVKEKVT RIILAAFRNL LEKSGEKETL
     QEYALAMIQC KVLKQLENLE QQKYDDEDIT EDIKFLLEKL GESVQDLSSF DEYSSELKSG
     RLEWSPVHKS EKFWRENAVR LNEKNYELLK ILTRLLEVSD DPQVIAVAAH DVGEYVRHYP
     RGKRVIEQLG GKQLVMNHMH HEDQLVRYNA LLAVQKLMVH NWEYLGRQLQ SSDQQQAPAV
     AARS
//