ID G3PZY6_GASAC Unreviewed; 515 AA.
AC G3PZY6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Dynamin-binding protein {ECO:0000256|ARBA:ARBA00018186};
DE AltName: Full=Scaffold protein Tuba {ECO:0000256|ARBA:ARBA00032587};
GN Name=ARHGEF38 {ECO:0000313|Ensembl:ENSGACP00000023176.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000023176.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000023176.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000023176.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Golgi apparatus, Golgi stack {ECO:0000256|ARBA:ARBA00004348}.
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DR AlphaFoldDB; G3PZY6; -.
DR STRING; 69293.ENSGACP00000023176; -.
DR Ensembl; ENSGACT00000023221.1; ENSGACP00000023176.1; ENSGACG00000017541.1.
DR eggNOG; KOG3519; Eukaryota.
DR GeneTree; ENSGT00950000183088; -.
DR InParanoid; G3PZY6; -.
DR OMA; QYTQEMV; -.
DR TreeFam; TF317245; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000017541; Expressed in liver and 3 other cell types or tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd12141; SH3_DNMBP_C2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR PANTHER; PTHR22834:SF17; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 38; 1.
DR Pfam; PF03114; BAR; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..68
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 110..326
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 366..429
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 451..514
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 515 AA; 59507 MW; 62909E7DE1BEC875 CRC64;
YRKIYDLEGK PNLLDMGSLI IKPVQRIMKY PLLLGELWHA TPEDHPDYHP LQKAFTAAKI
INVNINEFKR RKDIVMKYKR LEDEGTLRGK LHKFNIHSIR KKGDRFAGYL KILTGVEPQV
RDEIFDREEK LFRSLEKAVR QLAKNVQCYL QHTQEMVSVA VQNVQDMEDI LKDPNKNLTN
GSSDTNGNDP YKHFKDSMAR LVLAPLSSLQ GMFTAPQKLI QKRYDKLLDY CSRLEPVSED
PPGPARRDYE ALNALLVEEL QRFNAAAYSI LTNCVVYLVA LLRGLMDKIL LRSPSIQQLP
APLSNIAEVQ NSIMEELNNL TFVKDNAQKL MERKVSFERQ RDKRIALPEV QHQTEEQRAW
LLAEYPVSRL YQLKRKCNGC QEQDLALLEG ELIALLEDTD PSGSSSRWLV HLLGAQGYVY
STFLKQYNPL RDSQRGGRRP NCCGAEDRRD REPVKFYAVY AFQARCDQEL TLQEYQHVRI
LQFHDLGGNK DWWLAEANGQ KGYVPANYLG KMSYA
//
