ID G3Q0F2_GASAC Unreviewed; 1079 AA.
AC G3Q0F2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ULK1 {ECO:0000313|Ensembl:ENSGACP00000023344.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000023344.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000023344.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000023344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3Q0F2; -.
DR STRING; 69293.ENSGACP00000023344; -.
DR Ensembl; ENSGACT00000023390.1; ENSGACP00000023344.1; ENSGACG00000017660.1.
DR eggNOG; KOG0595; Eukaryota.
DR GeneTree; ENSGT00940000156664; -.
DR InParanoid; G3Q0F2; -.
DR OMA; HEWEVAV; -.
DR TreeFam; TF324551; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000017660; Expressed in camera-type eye and 12 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006914; P:autophagy; IEA:UniProt.
DR GO; GO:0010506; P:regulation of autophagy; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR045269; Atg1-like.
DR InterPro; IPR048941; ATG1-like_MIT2.
DR InterPro; IPR022708; Atg1-like_tMIT.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24348; SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED; 1.
DR PANTHER; PTHR24348:SF19; SERINE_THREONINE-PROTEIN KINASE ULK1; 1.
DR Pfam; PF12063; ATG1-like_MIT1; 1.
DR Pfam; PF21127; ATG1-like_MIT2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..302
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 325..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 63
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1079 AA; 116716 MW; 69EA50B757894AD4 CRC64;
RVIRPARSPA RPSSSNSAIR LRRAMETVGK FEFSRKDLIG HGAFAVVFKG RHREKHDWEV
AVKCINKKNL AKSQTLLGKE IKILKELKHE NIVALLDFQE TASSVYLVME TQYCNGGDLA
DYLHTKGTLS EDTIRVFLQQ IAGAMRVLQG KGIIHRDLKP QNILLSYPPG RRSHSNNTCI
KIDFVPTADF GFARYLQSNM MAATLCGSPM YMAPEVIMSQ SYDAKADLWS IGTIVFQCLI
GKAPFQASSP QDLRLFYEKN KTLSPNIPRE TSSHLRHLLL GLLQRNHKDR MDFDEFFCHP
FLEASSSLKK STPAVSMTCI PSSASASSCS SSSTSHLASP PSLAEGQHLR AKALASPTQE
AAGFLLKDSS GGAGSSKNSS SCDTDDFVMV PAHFTTGELT CESKVLQDSL MNSGSSLLAS
AGLCGQVKTP PQSPPCSGSP SPVSRPSEFS GSSCGGSYGN HCRSSPIPVP SQVQNYQRME
QNMHCTRLDG SPRPSAPVRR CSSGSSLGFA RAGPSPPCGQ GAAHANRRLS LGGARPFQPS
PQGTAEASPL WTSSTTAAGE QKHSDLCPPP TAPQPHPQQA PGLGARLHSA PSLLECTGAA
GKQKIRKQHS DPAVAPSAGL KTLRPLHSSP RLSELMQRSP LPTILGSPSR AIPPFEFPKP
PSSPNLVTFL TQQGLVIGSP CSRTAPPEPR DVGQRALTQV IQPAHCIHRR SDDAKVFGRS
QSAGRLSDML LMAAFGPGGP VGDRDSAENL TSEKTIDIMV PPGGGGSPAP GSISPAQVVF
TVGSPPSASS PPHTSRQRKY SVNPTMSSSG SFTSRYPQTC TYLDGFEAPS SPRYGFTDPI
TANMGGRVTF EPPELPEETL MEQEHTDIVQ SLRFTLDFAR CLMEVAGACG VAALREQEDV
SHPCLLQQQS VVADQISSLS REWSHAEQLV LYLKTAELLS TALHTAMERV KQGKLYPSST
VKQIVRRLNE LYKSSVASCR SLSTRLERFF SRKHRLMDQI TSITAERLLF SHTVQMVQTA
ALDEMFHQGE ASVLRYHKAL LLMEGLSLLL TEQDDILSVS KCKECIERRL TALQSGLCV
//
