ID G3Q1B8_GASAC Unreviewed; 936 AA.
AC G3Q1B8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Complement component 6 {ECO:0000313|Ensembl:ENSGACP00000023666.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000023666.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000023666.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000023666.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; G3Q1B8; -.
DR STRING; 69293.ENSGACP00000023666; -.
DR Ensembl; ENSGACT00000023712.1; ENSGACP00000023666.1; ENSGACG00000017908.1.
DR eggNOG; ENOG502QPIM; Eukaryota.
DR GeneTree; ENSGT00940000156814; -.
DR InParanoid; G3Q1B8; -.
DR OMA; CWGPWSR; -.
DR TreeFam; TF330498; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000017908; Expressed in liver.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 1.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR048828; C6_KAZAL.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF4; COMPLEMENT COMPONENT C6; 1.
DR Pfam; PF21288; C6_KAZAL; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 3.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..936
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003450380"
FT DOMAIN 178..522
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 641..700
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 701..764
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 148..166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 160..175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 671..698
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 703..746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 936 AA; 105351 MW; 6E091407144F7BF7 CRC64;
MAASGRLVLM LQLFSWTSVG MACFCDRYPW GSWSACSKTC NHGTQHRYRQ YQYDDGYYWK
NSCQQLCNRH DERACNEQNC PINCRLTDFG SWSDCSPCAK KQFRTRSVQR PSQFGGSSCS
VELTEDRPCY PSTDCKLPPI DCRSDFKCDT GRCINSTLTC NSQNDCGDNS DERECAGFKI
VCQSGKRVAP GASRVENGFD ALAEKQRSAV LDNMFMGGSC IIRRPPSTLL YHRIPHNFES
FDIKVGELGD FSTEPHVVKT EPIDIKKSSS SAKKEKDSDF LFALLYIGGG SRNQVSSNKE
AFEASKKKES KFFRVHQVLP VSTFKVRDPA DLVLSQPFLQ FLHALPLEYN YALYRDIFQR
FGTHYYSAGK LGGVYDLLYQ YSREELTSSG ETEEHTKDCL NRDTAWTAIL YTQYSSVTRC
SDNRMTEKYH GSYIEAAEKS FSSTRGGRPR EAAALVWERQ GAAPNKTSYK DWAKSVLDNP
DVVEYEVLPI IDLVRGIPCA TTKRRHLRKA LLQYLEEFDT CKCSPCPNNA RPVLSGTECQ
CLCQTGTFGT NCEKRAPDFT SEVVDGYWSC WGPWSGCGGS MKRHRRRRCD NPAPLRGGQP
CEGPDSNEEA CHVSIFERQQ TCDNDDDFTA GWSDELPPGV QGCRRPQRLA NSFLRKAKRY
YDFGEDEHFA CFTGFELEGF QYINCLPDGS WSQPKGRCIK KLCLPFEIPE GMMLYPNKDQ
FKVGEHVGLN CNETNLFPVP SGLYRCKEDL TWDPPLPADL RCTDEEPFVP EGGCGLGEKL
LHSKCLCIPR ESCLSQPESL CILNLDIDVT VPMSLCSFRA GRCHGDPLFF VAEGACDAVD
SAKLEWAKFR ANMSSKSSVQ TPCDLDTCYD WETCSASKTC VCKEARTCPP QGPEKTFCVK
LKTIRKSRSM SLCLIAALKC VNTQIEILNE GVCESR
//
