ID G3Q2U1_GASAC Unreviewed; 554 AA.
AC G3Q2U1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Ral GEF with PH domain and SH3 binding motif 1 {ECO:0000313|Ensembl:ENSGACP00000024190.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000024190.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000024190.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000024190.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3Q2U1; -.
DR STRING; 69293.ENSGACP00000024190; -.
DR Ensembl; ENSGACT00000024238.1; ENSGACP00000024190.1; ENSGACG00000018302.1.
DR eggNOG; KOG3417; Eukaryota.
DR GeneTree; ENSGT00940000154079; -.
DR InParanoid; G3Q2U1; -.
DR OMA; MVLCFSD; -.
DR TreeFam; TF352150; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000018302; Expressed in camera-type eye and 9 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13310; PH_RalGPS1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF167; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR RALGPS1; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 49..288
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 428..540
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 62319 MW; 5C33B1D8D57000EE CRC64;
MYRRNGLSDG TSIHSVTSEA SSSSDSLDAP CVDFAKSYDA VVFDVLKVTP EEFASQITLM
DAPVFKAIHP EELASCGWIG KEKHRLSPNV VAFTRRFNQV SFWLVREILT AQTLKIRAEI
LSHFVKIAKK LLELNNLHSL VSVVSALQSA PIFRLSKTWA LISRKDKATF EKLNYLTSKE
ENYTRMREYI RSLKMVPRIP YLGIYLLDMI YIDSAYPASD SILETEQRTN QMNNLLRLIS
DLQMSCNYDH LVTLPHVQKY LLSVRYIEEL QKFVEDDNFK LSLKIEPGNS SPRIASSKED
LAGLSEVSAP LRYNRRPTCP DASVGVGVPT PPPSHHRKSH SLGNNMMCQY GMSHSRSATF
PTEKARHLLD DSFLESQSPV RTEPHSTSVS NGLSLGSSES SFGEELSPGM ESLLLRSSPL
RGCSEASSVT VEGPLRRKTM LKEGRKPKLS SWTRFWIVLS GSTLTFFGAK ALRASERKHY
KSSPCKKVCV TGWMVVLPDD PARPNIFHLN DPDKGNVYKF QTGSRFSAII WHKNLEEACR
SSRPQIPANL MSFE
//
