ID G3Q4B1_GASAC Unreviewed; 966 AA.
AC G3Q4B1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN Name=PIGG {ECO:0000313|Ensembl:ENSGACP00000024715.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000024715.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000024715.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000024715.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
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DR AlphaFoldDB; G3Q4B1; -.
DR STRING; 69293.ENSGACP00000024715; -.
DR Ensembl; ENSGACT00000024764.1; ENSGACP00000024715.1; ENSGACG00000018696.1.
DR eggNOG; KOG2125; Eukaryota.
DR GeneTree; ENSGT00910000144269; -.
DR InParanoid; G3Q4B1; -.
DR OMA; RVKFGHD; -.
DR TreeFam; TF300609; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000018696; Expressed in intestinal epithelial cell and 4 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 738..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..790
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..887
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 907..926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 938..956
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 546..941
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 966 AA; 106981 MW; 9C2EB073F475B135 CRC64;
MKVRSSVFAS FILILEAVGV ALFLRGFFPV PLKSSLSSKS KLSDLPAEPL AGSSPNSSRL
PQPLFKRVVI MLVDALREDF VFGPNGRSYM PYTRHLVERG SSHSFVAKAR PPTVTMPRIK
ALTTGTIPGF IDVVMNLNSP ALLEDNLVWQ AKAAGKRMVF YGDDTWVRLF PKHFMEHDGT
TSFFVSDYTE VDNNVTRHLD STLKRDDWDI LILHYLGLDH IGHISGPHSS LIQPKLLEMD
DVLKKIHGAL VSKEAEGSLP YLLVLCGDHG MSETGSHGGS SEPEVNTPLV LISPAFKRKV
GMEKPEVVEQ VDLTPTLALG LGLPISQNSV GRLIPGVLEE TSLRDQLRFL HLNGHQLSCL
LKDSTPDYEK EAGFEQFRMA ERAHGSWMKL FLEGNTSEVL TNMGRKVLKQ YLEALASMSS
ALSKQLGKYD MYSMVAGMVF VFQLLLVLLL AMPEALSGEA TVDLPVLSAL LSLPFYLLCL
LLASVHVLVC TSAESSCYFC SLSWGLVFAA VALSSAMFCI LISMAMRRLP LGPLIHGKSP
SRSSEWSLSE LDVLLLAGTV GHTLSLAASS FVEEEHQIWY FLLNTLCLAV FQDVCRKYFR
EQSASGDEEE PVLPSRDCHP SARSRAEVLP ERWLALATPP FTLVCCRLLR SLNQTGVQWA
HLPDVGHWLN SSEHRTLLSL LAAFCLFLIY FLVQRRCSWV SKVALALGLL GVYSYRAAVG
NVGFPWQRSG SATSKGTVEA RFVYVFILGI LFTGTKDLLR SQIVTADAEL KSRGLWEIYS
GLVLLVSLLF RAHNLPVLCC CLLIQTLMAQ FIWKRLHYDA AQTTIMHYWF GQAFFYFQGN
SNNIATVDIS VGFVGLESYV EAPAVFLTAL NTYAGPLLWA CHLVCYLSSE RGRRSPVAVG
HGCYCLALLR SVPAAAYIVL VTALRYHLFI WSVFSPKLLY ESMHLLLTAG VCLFFITMEQ
SPGSSK
//