ID G3Q4B7_GASAC Unreviewed; 473 AA.
AC G3Q4B7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Programmed cell death protein 4 {ECO:0000256|ARBA:ARBA00014414};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000024721.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000024721.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000024721.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PDCD4 family.
CC {ECO:0000256|ARBA:ARBA00005497}.
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DR STRING; 69293.ENSGACP00000024721; -.
DR Ensembl; ENSGACT00000024770.1; ENSGACP00000024721.1; ENSGACG00000018691.1.
DR Ensembl; ENSGACT00000024771.1; ENSGACP00000024722.1; ENSGACG00000018691.1.
DR eggNOG; KOG0403; Eukaryota.
DR GeneTree; ENSGT00390000015948; -.
DR OMA; GMEQGFI; -.
DR TreeFam; TF323207; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000018691; Expressed in telencephalon and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003171; P:atrioventricular valve development; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR039778; PDCD4.
DR PANTHER; PTHR12626; PROGRAMMED CELL DEATH 4; 1.
DR PANTHER; PTHR12626:SF3; PROGRAMMED CELL DEATH PROTEIN 4; 1.
DR Pfam; PF02847; MA3; 2.
DR SMART; SM00544; MA3; 2.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS51366; MI; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 167..288
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 330..453
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT REGION 58..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 52393 MW; 2BBAB9AC7A993811 CRC64;
MATDCAAWLN AIPAEAEDLS DSLVSEEEDN TGSVVNKNLK NELNGNWLSS ASSSIHEARL
KAKAKRRLRK NSSRDSGRGD SFSDNGDVVR GTSVAPASPK SKLLDRKSRL GKGRGLPKKG
GAGGKGVWGR SGEVYEQEAV DQKDPNYDEA QENCVYETVV PPLDERDFEN TVSPILQEYF
EHGDTNEVAE LLAELNLGPM RSEVPSLAVS LALEAKASHR ELTSRLLADL CGPVLSRGDM
EISFDKLLLE LPDLVLDTPG APQLVGQFIA QAVSDQILSK SYIEAYKGRV DCEYTRVSLD
RAAVLLRMSM EGLRIDNQWG AGGGQRPVTQ LVKEMNLLLK EYILSGDSKE AERCLRDLEV
PHFHHEFVYE AIVMVLESKG EKTLEMVLQL LKSLSVSTVI TLDQMRRGYE RVYMDIAEIN
IDVPRAYFLL EQFVDRSFSM GVIDVKLRDL CPCRGRKRFI SEGDGGVVKA ESY
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