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Database: UniProt
Entry: G3Q5Z1_GASAC
LinkDB: G3Q5Z1_GASAC
Original site: G3Q5Z1_GASAC 
ID   G3Q5Z1_GASAC            Unreviewed;       215 AA.
AC   G3Q5Z1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Metalloproteinase inhibitor 3 {ECO:0000256|ARBA:ARBA00013517};
DE   AltName: Full=Tissue inhibitor of metalloproteinases 3 {ECO:0000256|ARBA:ARBA00030101};
GN   Name=TIMP3 {ECO:0000313|Ensembl:ENSGACP00000025297.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000025297.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000025297.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000025297.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC       {ECO:0000256|ARBA:ARBA00011027}.
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DR   AlphaFoldDB; G3Q5Z1; -.
DR   STRING; 69293.ENSGACP00000025297; -.
DR   MEROPS; I35.003; -.
DR   Ensembl; ENSGACT00000025346.1; ENSGACP00000025297.1; ENSGACG00000019129.1.
DR   eggNOG; KOG4745; Eukaryota.
DR   GeneTree; ENSGT00940000159601; -.
DR   InParanoid; G3Q5Z1; -.
DR   OMA; RGFDKMP; -.
DR   TreeFam; TF317409; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000019129; Expressed in spleen and 12 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd03585; NTR_TIMP; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR001820; TIMP.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   InterPro; IPR027465; TIMP_C.
DR   PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR   PANTHER; PTHR11844:SF22; METALLOPROTEINASE INHIBITOR 3; 1.
DR   Pfam; PF00965; TIMP; 1.
DR   SMART; SM00206; NTR; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601820-3};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW   Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW   Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           28..215
FT                   /note="Metalloproteinase inhibitor 3"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003450599"
FT   DOMAIN          28..147
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
FT   BINDING         28
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="ligand shared with metalloproteinase partner"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT   DISULFID        28..95
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        30..122
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        40..147
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        149..196
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        154..159
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        167..188
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ   SEQUENCE   215 AA;  24748 MW;  B0772E1E81366258 CRC64;
     QNAVREQQLV GLLLVFGSLQ VVRVTEGCSC ALSHPQDAFC NSDVVIRAKV VGKKPLRDGP
     FGTMRYTVKQ MKMYKGFEKV QHVQHIYTDA SESLCGVKFD INKYQYLITG RVYDGKVYTG
     LCNFNERWER LSLAQKKGFN HRYQLGCKCR IKSCHYLPCF VTSKNECLWT DMLSHFGYPG
     YQSRHYACIQ QKEGYCSWYR GMASRDKTTI NATDP
//
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