ID G3Q5Z1_GASAC Unreviewed; 215 AA.
AC G3Q5Z1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Metalloproteinase inhibitor 3 {ECO:0000256|ARBA:ARBA00013517};
DE AltName: Full=Tissue inhibitor of metalloproteinases 3 {ECO:0000256|ARBA:ARBA00030101};
GN Name=TIMP3 {ECO:0000313|Ensembl:ENSGACP00000025297.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000025297.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000025297.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000025297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC {ECO:0000256|ARBA:ARBA00011027}.
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DR AlphaFoldDB; G3Q5Z1; -.
DR STRING; 69293.ENSGACP00000025297; -.
DR MEROPS; I35.003; -.
DR Ensembl; ENSGACT00000025346.1; ENSGACP00000025297.1; ENSGACG00000019129.1.
DR eggNOG; KOG4745; Eukaryota.
DR GeneTree; ENSGT00940000159601; -.
DR InParanoid; G3Q5Z1; -.
DR OMA; RGFDKMP; -.
DR TreeFam; TF317409; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000019129; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd03585; NTR_TIMP; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR027465; TIMP_C.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF22; METALLOPROTEINASE INHIBITOR 3; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..215
FT /note="Metalloproteinase inhibitor 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003450599"
FT DOMAIN 28..147
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT BINDING 28
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared with metalloproteinase partner"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT DISULFID 28..95
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 30..122
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 40..147
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 149..196
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 154..159
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 167..188
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 215 AA; 24748 MW; B0772E1E81366258 CRC64;
QNAVREQQLV GLLLVFGSLQ VVRVTEGCSC ALSHPQDAFC NSDVVIRAKV VGKKPLRDGP
FGTMRYTVKQ MKMYKGFEKV QHVQHIYTDA SESLCGVKFD INKYQYLITG RVYDGKVYTG
LCNFNERWER LSLAQKKGFN HRYQLGCKCR IKSCHYLPCF VTSKNECLWT DMLSHFGYPG
YQSRHYACIQ QKEGYCSWYR GMASRDKTTI NATDP
//