ID   G3Q642_GASAC            Unreviewed;      1041 AA.
AC   G3Q642;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000025348.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000025348.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000025348.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   AlphaFoldDB; G3Q642; -.
DR   STRING; 69293.ENSGACP00000025348; -.
DR   Ensembl; ENSGACT00000025397.1; ENSGACP00000025348.1; ENSGACG00000019171.1.
DR   eggNOG; KOG2108; Eukaryota.
DR   GeneTree; ENSGT00390000011669; -.
DR   InParanoid; G3Q642; -.
DR   OMA; CERCVWT; -.
DR   TreeFam; TF329020; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000019171; Expressed in liver and 13 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   CDD; cd18786; SF1_C; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          212..266
FT                   /note="F-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50181"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1041 AA;  117167 MW;  095DF8ED9E58918C CRC64;
     MEMAVKGKAK RRHLNAGECD ELARRTEGTN ALTQPHTVNG RGTRSANRGL YPRTPTKRRK
     CGSPSGHQKA IDNFFSVTRV IRSSPHKFPQ PGSSTCTNVL NGNRFPEKET GVMTEDDDDD
     DDVSFLAPPS APNPEEEWEE EVDNVSPLAA ESMPKNEHGV DHLEGMTAEI FGDDDEFVQW
     DRESHDMEEE VEALPDAHYG LLGSRKVLLK PEGCMDDLPE EVLRQILCLV TAQELYRCVS
     LVCHHWRNIV QDTKFVPFKK QYFRYMMREK ETVQEICSVL RNSSITDPSS SQHSIRSLVV
     LMAQHAVGER VRPQDVLDCV KKHRLFPQAE ASIRLRIPDI QKFFNGPNPY AAMAVILILS
     ESVGDVQALV SLLTGCMSQT AITEYFSHMA MMLLAVKRNH IKISSRLHYN IYYTLHLMDN
     GPFTVGSGTS GRPQVQLTGE QQQILSHDVQ KDHVIKIVAF AGTGKTTTLV KYAEQRPHLR
     FLYVAFNKSV ASEAQRRFPR NVTCKTVHSL AFADVGRRYQ SCRKLTFDLK PFAINSVLPE
     HRGGFARAKV VSTTLRTFMA SPDENLTVAH VPYVRINRHR EREAILEPER KLFADEALTI
     WNKMKDLNET KVDAYHMTHD GYLKLWQLQV PKPCLSQQYD VLFIDEAQDC TPVILDVFLA
     QSCGKILVGD PHQQIYTFRG AVNALNLIDH THIFYLTQSF RFGAEIAYVG ATILKECKRV
     EKILVGGKQK ALMEGVSLCP GKTAILSRCN VTVFGEAVRL TDSNPQCRLH FIGGVGGIGL
     NRILDIWKLL EGTKQTTLAL SSGVRDPLIR CFANKQNGVW AFRKYVQQTN DLELETKLSI
     VEKYRKRIPE LVKRLEMCFE EDIHKADFIL GTVHKAKGLE FDTVMVTDDF AKVPSSNHNL
     HFNPDFSFSK LADDEWNLLY VAVTRARTSL IITKSIRRLL TVAGEYFLKS EMPPGTPLVG
     DPLPCCISEC PNCTTPGSAF IMSKTQMKCS DGVSAGGPLC ERCVWTRIGS TAFLMTDDVL
     SMAEIPRGLV HLDNRMLLGL F
//