ID G3Q6U6_GASAC Unreviewed; 607 AA.
AC G3Q6U6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000025606.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000025606.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000025606.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3Q6U6; -.
DR STRING; 69293.ENSGACP00000025606; -.
DR Ensembl; ENSGACT00000025656.1; ENSGACP00000025606.1; ENSGACG00000019374.1.
DR eggNOG; KOG3512; Eukaryota.
DR GeneTree; ENSGT00940000153882; -.
DR InParanoid; G3Q6U6; -.
DR OMA; ESHPESM; -.
DR TreeFam; TF352481; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000019374; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0021960; P:anterior commissure morphogenesis; IEA:Ensembl.
DR GO; GO:0033564; P:anterior/posterior axon guidance; IEA:Ensembl.
DR GO; GO:0048846; P:axon extension involved in axon guidance; IEA:Ensembl.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR GO; GO:0061386; P:closure of optic fissure; IEA:Ensembl.
DR GO; GO:0016358; P:dendrite development; IEA:Ensembl.
DR GO; GO:0003146; P:heart jogging; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0048665; P:neuron fate specification; IEA:Ensembl.
DR GO; GO:0071678; P:olfactory bulb axon guidance; IEA:Ensembl.
DR GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IEA:Ensembl.
DR GO; GO:0030516; P:regulation of axon extension; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR GO; GO:0035908; P:ventral aorta development; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03579; NTR_netrin-1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..607
FT /note="Netrin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003450547"
FT DOMAIN 46..285
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 286..341
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 405..454
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 475..604
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 288..305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 307..316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 405..417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 407..424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 426..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 438..452
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 607 AA; 67681 MW; A2CD01CF59F11FBE CRC64;
MRAVDVALAV LLAASLSCRS ALGGYGASLF AAQTSPPDPC NDEHGNPRRC IPDFVNAAFG
KDVRASSSCG KTPGRYCVVT AAEKGDERTR SCHTCDASDP KKCRPPAYLT DLNNPHNLTC
WQSENFVQYP QNVTLTLSLG KKFEVTYVSL QFCSPRPESM VIYKSMDYGK TWVPFQFYST
QCRKMYNKPN RAAITKQNEQ EAVCTDSHTD MYPLTGGLIA FSTLDGRPSA HDFDNSPVLQ
DWVTATDVKV IFSRLHTFGD ENEDDSEVAR DSYFYAVSDL QVGGRCKCNG HASRCVKDRD
GGLVCECKHN TGGPECDRCK PFHYDRPWQR ATAREANECV ACNCNLHARR CRFNMELYKL
SGRKSGGVCL NCRHNTAGRH CHYCKEGYYR DLSKPISHRK ACKACDCHPV GAAGKTCNQT
TGQCPCKDGV TGITCNRCAK GYQQSRSPIA PCIRVEIPVA PPTTPSSSTE EPSDCDSYCK
ASKGKLKINM KKYCKKDYAV QVHILKADKS GEWWKFTVNI ISVYKQGESR IRRGDQFLWV
RAKDVACKCP KIKPGKKYLL LGNDEDSPGQ GGVVADKGSL VIQWRDTWAR RLRKFQQREK
NGKCKKP
//
