ID   G3Q9P9_GASAC            Unreviewed;       624 AA.
AC   G3Q9P9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=HHIP like 1 {ECO:0008006|Google:ProtNLM};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000026614.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000026614.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000026614.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the HHIP family.
CC       {ECO:0000256|ARBA:ARBA00010658}.
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DR   AlphaFoldDB; G3Q9P9; -.
DR   Ensembl; ENSGACT00000026665.1; ENSGACP00000026614.1; ENSGACG00000020144.1.
DR   GeneTree; ENSGT00940000162083; -.
DR   OMA; YSVEVRY; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000020144; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR018143; Folate_rcpt-like.
DR   InterPro; IPR012938; Glc/Sorbosone_DH.
DR   InterPro; IPR011041; Quinoprot_gluc/sorb_DH.
DR   PANTHER; PTHR19328; HEDGEHOG-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR19328:SF32; HHIP-LIKE PROTEIN 1; 1.
DR   Pfam; PF03024; Folate_rec; 1.
DR   Pfam; PF07995; GSDH; 1.
DR   SUPFAM; SSF50952; Soluble quinoprotein glucose dehydrogenase; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..624
FT                   /note="HHIP like 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003450743"
FT   DOMAIN          48..195
FT                   /note="Folate receptor-like"
FT                   /evidence="ECO:0000259|Pfam:PF03024"
FT   DOMAIN          205..524
FT                   /note="Glucose/Sorbosone dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF07995"
SQ   SEQUENCE   624 AA;  70644 MW;  3BF7D56E12721DF7 CRC64;
     MRRGPGRVPR GLRVSPLVFW CVALCGAPAA SHPQCLDFKP PFRPLRELEF CVMYKEFGCC
     DYQRDQELMA NYYHVMGGSD YSGYVRCAGF VLELLCQQCS PYAAHLFDAE DPNTPVRTIP
     GLCPDYCSEF WKKCSSTIPL LSNDTLIAKL KEDQTRLCQY LKLDDDDYCY PHLLSNQKLT
     QNLGTVQSDS EGCLQLCLEE VANGLRNPLA MVHANDGTHR FFVAEQVGLV WTYLSERSKL
     DIPFLNITKT VLTSSWEGDE RGFLGLTFHP KYKYNGKLYV YYSVEVGFDE RIRISEFHVS
     ANDMNVVDHA SERVILEIDE PASNHNGGQL LFADDGYLYV FTGDGGMAGD PFGKYGNAQN
     KSSLLGKVLR IDVDDNERGP LYRIPPNNPF IHERGARPEI YAYGVRNMWR CSVDRGDPQT
     KEGKGRIFCG DVGQNKFEEI DIIEKGRNYG WRAKEGFSCY DKKLCANSSL DDVLPIYAYP
     HKMGKSVTGG YVYRGCEYPN LNGMYIFGDF MSGRLMSLRE DRNTGRWKYN EICMGMGLTC
     AFPALINNYH QYIISFAEDE AGELYFMSTR IPSATSPSGV IYKVVDPSRQ KRVKSNLIKF
     VPEERTGAPC VTTCGPPKML QWYA
//