ID G3QBF9_GASAC Unreviewed; 968 AA.
AC G3QBF9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Glutamate receptor, metabotropic 5a {ECO:0000313|Ensembl:ENSGACP00000027225.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000027225.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000027225.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000027225.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; G3QBF9; -.
DR Ensembl; ENSGACT00000027277.1; ENSGACP00000027225.1; ENSGACG00000020586.1.
DR GeneTree; ENSGT01030000234595; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000020586; Expressed in telencephalon and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15450; 7tmC_mGluR5; 1.
DR CDD; cd06374; PBP1_mGluR_groupI; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000202; GPCR_3_mGluR5.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF165; METABOTROPIC GLUTAMATE RECEPTOR 5A; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01055; MTABOTROPC5R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..968
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003450526"
FT TRANSMEM 597..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 665..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 750..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 815..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 595..857
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 968 AA; 109166 MW; 70FD979ED1F88CA7 CRC64;
MGDRLGLYVR LIAVSALLGA DLSRLGLKDQ GGVNAQTTDR RVLTHIPGDI IIGALFSVHH
QPPADKVHER KCGAVREQYG IQRVEAMMHT LDRINADPTI LPNITLGCEI RDSCWHSAVA
LEQSIEFIRD TLVSNEEEES HGRCTAEAGS MLLQAKKPIV GLIGPGSSSV AIQVQNLLQL
FNIPQIAYSA TSMDLSDKSL YKYFMRVVPS DMQQAKAMVD IVKKYNWSYV SAIHTEGNYG
ESGMEAFKDM AAKEGICIAH SDKIYSNAGE QSFDKLLQKL RAHLPKARVV ACFCEGMTVR
GILMAMRRQR LVGEFLLVGS DGWADRYDVT DGYEREAAGG ITIKLKSAYV TWFDDYYLNL
KPDANLRNPW FPEFWQHRFQ CKLIGHPQES SLYNRTCTWR ESLRHQYAQD TKMGFVINAI
YSMAYGLHAM QQSLCPGYKG LCETMRPIDG RKLLDFLMRT NFTGVSAETI YFDQNGDSPG
RYEIMNFKRT GEDEYSYNHV GSWDQGGLKM NDEEIWSNNS EIIQSVCSEP CQKAQIKVIR
KGEVSCCWTC TPCKENEFVF DEYTCRACVL GFWPTDDLTG CEPIPVQYVR WGDPEPIAAV
AFSCLGLMAT LFVTSVFIKF WDTPVVKSSS RELCYIILVG ICLGYLCTFS LIAKPHIVYC
YLQRLGIGLS PAMSYSALVT KTNRIARILA GSKKKICTKK PRFMSACAQL VIAFLLILLQ
FGIIVALFII EPPEVIYDYP SIREVHLICN LTTLGVVAPL GYNGLLILSC TFYAFKTRNV
PANFNEAKYI AFTMYTTCII WLAFVPIYFG SNYKIITMCF SVSLSATVAL CCMFVPKVYI
MLAKPEKNVR SAFTTSTVVR MHVGDAKKVT KTGKSSSSMA NLFRRRGSVQ DNTRYMGDLS
GYYAMNKFPW FHKMPSYVLR AFRSSNGKSV TWSQNERGHR PNIWKRMSFH VKKKEVVETN
QTAIIKPF
//
