ID G3QDZ8_GORGO Unreviewed; 523 AA.
AC G3QDZ8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Dynein regulatory complex subunit 3 {ECO:0000256|ARBA:ARBA00040950};
GN Name=DRC3 {ECO:0000313|Ensembl:ENSGGOP00000000481.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000000481.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000000481.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000000481.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000000481.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000256|ARBA:ARBA00004611}.
CC -!- SIMILARITY: Belongs to the DRC3 family.
CC {ECO:0000256|ARBA:ARBA00038378}.
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DR EMBL; CABD030039170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030039171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004042208.1; XM_004042160.2.
DR AlphaFoldDB; G3QDZ8; -.
DR STRING; 9593.ENSGGOP00000000481; -.
DR Ensembl; ENSGGOT00000000493.3; ENSGGOP00000000481.2; ENSGGOG00000000489.3.
DR KEGG; ggo:101148886; -.
DR GeneTree; ENSGT00940000159298; -.
DR HOGENOM; CLU_026827_0_0_1; -.
DR InParanoid; G3QDZ8; -.
DR OMA; SFMEMMT; -.
DR OrthoDB; 24160at2759; -.
DR Proteomes; UP000001519; Chromosome 5.
DR Bgee; ENSGGOG00000000489; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF12; DYNEIN REGULATORY COMPLEX SUBUNIT 3; 1.
DR PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00022846};
KW Cilium {ECO:0000256|ARBA:ARBA00022846};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT COILED 209..236
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 523 AA; 60993 MW; 59932BA45B2A06DB CRC64;
MNRPCNSMEP RVMDDDMLKL AVGDQGPQEE AGQLAKQEGI LFKDVLSLQL DFRNILRIDN
LWQFENLRKL QLDNNIIEKI EGLENLAHLV WLDLSFNNIE TIEGLDTLVN LEDLSLFNNR
ISKIDSLDAL VKLQVLSLGN NRIDNMMNII YLRRFKCLRT LSLSRNPISE AEDYKMFICA
YLPDLVYLDY RRIDDHTKEL AEAKHQYSID ELKHRENLMQ AQLEDEQARR EELEKHKTAF
VEHLNGSFLF DSMYAEDSEG NKLSYLPGVG ELLETYKDKF VIICVNIFEY GLKQQEKRKT
ELDTFSECVH EAIQENQEQG KRKIAKFEEK HLSSLSAIRE ESELPNIEKM ILECSADISE
LFDALMTLEM QLVEQLEETI NMFERNIVDM VGVFIENVQS LMAQCRDLES HHHEKLLEIS
ISTLEKIVEG DLDEDLPNDL RALFVDKDTI VNAVGASHDI HLLKIDNRED ELVTRINSWC
TRLVDKIHKD EIMRNRKRVK EINQYIDHMQ SELDNLECGD ILD
//
