ID G3QEF5_GORGO Unreviewed; 537 AA.
AC G3QEF5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Polypyrimidine tract binding protein 2 {ECO:0000313|Ensembl:ENSGGOP00000000648.3};
GN Name=PTBP2 {ECO:0000313|Ensembl:ENSGGOP00000000648.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000000648.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000000648.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000000648.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000000648.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030004720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030004721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030004722; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030004723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030004724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018889563.1; XM_019034018.1.
DR AlphaFoldDB; G3QEF5; -.
DR SMR; G3QEF5; -.
DR STRING; 9593.ENSGGOP00000000648; -.
DR Ensembl; ENSGGOT00000000664.3; ENSGGOP00000000648.3; ENSGGOG00000000659.3.
DR GeneID; 101143153; -.
DR CTD; 58155; -.
DR eggNOG; KOG1190; Eukaryota.
DR GeneTree; ENSGT01050000244924; -.
DR HOGENOM; CLU_015171_7_0_1; -.
DR InParanoid; G3QEF5; -.
DR OMA; IHHVLYP; -.
DR OrthoDB; 4825346at2759; -.
DR TreeFam; TF319824; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000000659; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005681; C:spliceosomal complex; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0006376; P:mRNA splice site recognition; IEA:Ensembl.
DR GO; GO:0033119; P:negative regulation of RNA splicing; IEA:Ensembl.
DR GO; GO:2000177; P:regulation of neural precursor cell proliferation; IEA:Ensembl.
DR GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR CDD; cd12778; RRM1_PTBP2; 1.
DR CDD; cd12783; RRM2_PTBP2; 1.
DR CDD; cd12696; RRM3_PTBP2; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035002; PTBP2_RRM1.
DR InterPro; IPR034799; PTBP2_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF16; POLYPYRIMIDINE TRACT-BINDING PROTEIN 2; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR PROSITE; PS50102; RRM; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 59..133
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 181..257
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 343..417
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 460..535
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 537 AA; 58084 MW; 35F5BFD2614647B3 CRC64;
MDGIVTEVAV GVKRGSDELL SGSVLSSPNS NMSSMVVTAN GNDSKKFKGE DKMDGAPSRV
LHIRKLPGEV TETEVIALGL PFGKVTNILM LKGKNQAFLE LATEEAAITM VNYYSAVTPH
LRNQPIYIQY SNHKELKTDN TLNQRAQAVL QAVTAVQTAN TPLSGTTVSE SAVTPAQSPV
LRIIIDNMYY PVTLDVLHQI FSKFGAVLKI ITFTKNNQFQ ALLQYGDPVN AQQAKLALDG
QNIYNACCTL RIDFSKLVNL NVKYNNDKSR DYTRPDLPSG DGQPALDPAI AAAFAKETSL
LGLPVAAVPG ALSPLAIPNA AAAAAAAAAG RVGMPGVSAG GNTVLLVSNL NEEMVTPQSL
FTLFGVYGDV QRVKILYNKK DSALIQMADG NQSQLAMNHL NGQKMYGKII RVTLSKHQTV
QLPREGLDDQ GLTKDFGNSP LHRFKKPGSK NFQNIFPPSA TLHLSNIPPS VAEEDLRTLF
ANTGGTVKAF KFFQRDHKMA LLQMATVEEA IQALIDLHNY NLGENHHLRV SFSKSTI
//
