ID G3QF65_GORGO Unreviewed; 571 AA.
AC G3QF65;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Adenosine deaminase domain containing 2 {ECO:0000313|Ensembl:ENSGGOP00000000930.3};
GN Name=ADAD2 {ECO:0000313|Ensembl:ENSGGOP00000000930.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000000930.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000000930.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000000930.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000000930.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; CABD030102464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QF65; -.
DR STRING; 9593.ENSGGOP00000000930; -.
DR Ensembl; ENSGGOT00000000951.3; ENSGGOP00000000930.3; ENSGGOG00000000944.3.
DR eggNOG; KOG2777; Eukaryota.
DR GeneTree; ENSGT00940000161900; -.
DR HOGENOM; CLU_005382_4_2_1; -.
DR InParanoid; G3QF65; -.
DR OMA; AKNFYFK; -.
DR TreeFam; TF315806; -.
DR Proteomes; UP000001519; Chromosome 16.
DR Bgee; ENSGGOG00000000944; Expressed in testis and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0008251; F:tRNA-specific adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0006382; P:adenosine to inosine editing; IBA:GO_Central.
DR GO; GO:0006396; P:RNA processing; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR Gene3D; 3.30.160.20; -; 1.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR014720; dsRBD_dom.
DR PANTHER; PTHR10910:SF106; ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 1.
DR SMART; SM00552; ADEAMc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 123..159
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 249..564
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
SQ SEQUENCE 571 AA; 61494 MW; 19FD156BE9AE12B0 CRC64;
PRVPVPPAGL SLPLKDPPAS QAVSLLTEYA ASLGIFLLFR EDQPPEKMFK YRAPGGEELK
AMCLWQVEVL RAFLLRTGWR GLWRGDLDLG PDTSWANRLP FLLICEMESR IPVVEELGPC
FPFSVSAELD GVVCPAGTAN SKTEAKQQAA LSALCYIRSQ LENPESPQTS SRPPLAPLSV
ENILTHEQRC AALVSAGFDL LLDERSPYWA CKGTVAGVIL ERGWAVSAPS CTEIPRARGH
VKEIYKLVAL GTGSSCCAGW LEFSGQQLHD CHGLVIARRA LLRFLFRQLL LATQGGPKGK
EQSVLAPQPG PGPPFTLKPR VFLHLYISNT PKGAARDIYL PPTSEGGLPH SPPMRLQAHV
LGQLKPVCYV APSLCDTHVG CLSASDKLAR WAVLGLGGAL LAHLVSPLYS TSLILADSCH
DPPTLSRAIH TRPCLDSVLG PCLPPPYVRT ALHLFAGPPV APSEPTPDTC RGLSLNWSLG
DPGIEVVDVA TGRVKANAAL GPPSRLCKAS FLRAFHQAAR AVGKPYLLAL KTYEAAKAGP
YQEARRQLSL LLDQQGLGAW PSKPLVGKFR N
//