ID G3QFC6_GORGO Unreviewed; 1101 AA.
AC G3QFC6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=IQ motif and Sec7 domain ArfGEF 1 {ECO:0000313|Ensembl:ENSGGOP00000000995.4};
GN Name=IQSEC1 {ECO:0000313|Ensembl:ENSGGOP00000000995.4};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000000995.4, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000000995.4, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000000995.4, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000000995.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BRAG family.
CC {ECO:0000256|ARBA:ARBA00006248}.
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DR EMBL; CABD030019944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030019945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3QFC6; -.
DR STRING; 9593.ENSGGOP00000000995; -.
DR Ensembl; ENSGGOT00000001017.4; ENSGGOP00000000995.4; ENSGGOG00000001008.4.
DR eggNOG; KOG0931; Eukaryota.
DR GeneTree; ENSGT00940000156915; -.
DR HOGENOM; CLU_004328_0_1_1; -.
DR InParanoid; G3QFC6; -.
DR OMA; AGHSAHH; -.
DR TreeFam; TF323811; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000001008; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13318; PH_IQSEC; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR033742; IQSEC_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF327; IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF16453; IQ_SEC7_PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 502..695
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 969..987
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1048
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1101 AA; 122953 MW; 647A937A2F2DD8A7 CRC64;
MGCQRMVVEG EAPSSETGTS LDSPSAYPQG PLVPSSSLSP DHYEHTSVGA YGLYSGPPGQ
QQRTRRPKLQ HSTSILRKQA EEEAIKRSRS LSESYELSSD LQDKQVEMLE RKYGGRLVTR
HAARTIQTAF RQYQMNKNFE RLRSSMSENR MSRRIVLSNM RMQFSFEGPE KVHSSYFEGK
QVSVTNDGSQ LGALVPPECG DLSEPTTLKS PAPSSDFADA ITELEDAFSR QVKSLAESID
DALNCRSLHT EEAPALDAAR ARDTEPQTAL HSMDHHKLDE MTASYSDVTL YIDEEELSPP
LPLSQAGDRP SSTESDLRLR AGGAAPDYWA LAHKEDKADT DTSCRSTPSL ERQEQRLRVE
HLPLLTIEPP SDSSVDLSDR SERGSLKRQS AYERSLGGQQ GSPKHGPHSG APKSLPREEP
ELRPRPPRPL DSHLAINGSA NRQSKSESDY SDGDNDSINS TSNSNDTINC SSESSSRDSL
REQTLSKQTY HKEARNSWDS PAFSNDVIRK RHYRIGLNLF NKKPEKGVQY LIERGFVPDT
PVGVAHFLLQ RKGLSRQMIG EFLGNRQKQF NRDVLDCVVD EMDFSTMELD EALRKFQAHI
RVQGEAQKVE RLIEAFSQRY CICNPGVVRQ FRNPDTIFIL AFAIILLNTD MYSPNVKPER
KMKLEDFIKN LRGVDDGEDI PREMLIGIYE RIRKRELKTN EDHVSQVQKV EKLIVGKKPI
GSLHPGLGCV LSLPHRRLVC YCRLFEVPDP NKPQKLGLHQ REIFLFNDLL VVTKIFQKKK
NSVTYSFRQS FSLYGMQVLL FENQYYPNGI RLTSSVPGAD IKVLINFNAP NPQDRKKFTD
DLRESIAEVQ EMEKHRIESE LEKQKGVVRP SMSQCSSLKK ESGNGTLSRA CLDDSYASGE
GLKRSALSSS LRDLSEAGKS LGSIISSPHM RRRATSTREC PSRPHQTMPN SSSLLGSLFG
SKRGKPPPQA HLPSAPALPP PHPPVILPHL QHSVAGHHLG PPEGLPQAPV HGHHTQYCHM
QQNPPPYHHH HHHHPPQHIQ HAHQYHHGPH GGHPAYGAHA HGHPPLPSAH VGHTAHHHGQ
PPAPPPPTSS KAKPSGISTI V
//
