ID G3QFT5_GORGO Unreviewed; 755 AA.
AC G3QFT5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=PWWP domain containing 2A {ECO:0000313|Ensembl:ENSGGOP00000001165.3};
GN Name=PWWP2A {ECO:0000313|Ensembl:ENSGGOP00000001165.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000001165.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000001165.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000001165.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000001165.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030041999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030042000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030042001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004042973.1; XM_004042925.2.
DR AlphaFoldDB; G3QFT5; -.
DR STRING; 9593.ENSGGOP00000001165; -.
DR Ensembl; ENSGGOT00000001189.3; ENSGGOP00000001165.3; ENSGGOG00000001181.3.
DR GeneID; 101143468; -.
DR KEGG; ggo:101143468; -.
DR CTD; 114825; -.
DR eggNOG; ENOG502QU6V; Eukaryota.
DR GeneTree; ENSGT00940000157692; -.
DR HOGENOM; CLU_020678_0_0_1; -.
DR InParanoid; G3QFT5; -.
DR OMA; TNSECST; -.
DR OrthoDB; 2904336at2759; -.
DR TreeFam; TF331271; -.
DR Proteomes; UP000001519; Chromosome 5.
DR Bgee; ENSGGOG00000001181; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0120325; F:NuRD complex binding; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0032968; P:positive regulation of transcription elongation by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0001178; P:regulation of transcriptional start site selection at RNA polymerase II promoter; IEA:Ensembl.
DR CDD; cd20152; PWWP_PWWP2A; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR InterPro; IPR000313; PWWP_dom.
DR PANTHER; PTHR16112; METHYL-CPG BINDING PROTEIN, DROSOPHILA; 1.
DR PANTHER; PTHR16112:SF22; PWWP DOMAIN-CONTAINING PROTEIN 2B; 1.
DR Pfam; PF00855; PWWP; 1.
DR SMART; SM00293; PWWP; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50812; PWWP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 655..715
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 578..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..80
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..134
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..494
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..534
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 755 AA; 81952 MW; 1302F11C1BEE804C CRC64;
MAAVAAEAAA TAASPGEGGA GEAEPEMEPI PGSEAGTDPL PVTATEASVP DGETDGQQSA
PQADEPPLPP PPPPPGELAR SPEAVGPELE AEEKLSVRVA ESAAAAPQGG PELPPSSASP
PEQPPAPEER EEPPLPQPVA LAFVPPAGGD STVSQLIPGS EVRVTLDHII EDALVVSFRL
GEKLFSGVLM DLSKRFGPHG IPVTVFPKRE YKDKPEAMPL QSNTFQEGTE VKCEANGAVP
DDPSPVPHPE LSLAESLWTS KPPPLFHEGA PYPPPLFIRD TYNQSIPQPP PRKIKRPKRK
MYREEPTSIM NAIKLRPRQV LCDKCKNSVV AEKKEIRKGS SASDSSKYED KKRRNESVTT
VNKKLKTDHK VDGKNQNESQ KRNAVVKVSN IAHSRGRVVK VSAQANTSKA QLSTKKVLQS
KNMDHAKARE VLKIAKEKAQ KKQNETSTSK NAHSKVHFTR RYQNPSSGSL PPRVRLKPQR
YRNEENDSSL KTGLEKMRSG KMAPKPQSRC TSTRSAGEAP SENQSPSKGP EEASSEVQDT
NEVHVPGDQD EPQTLGKKGS KNNISVYMTL NQKKSDSSSA SVCSIDSTDD LKSSNSECSS
SESFDFPPGS MHAPSTSSTS SSSKEEKKLS NSLKMKVFSK NVSKCVTPDG RTICVGDIVW
AKIYGFPWWP ARILTITVSR KDNGLLVRQE ARISWFGSPT TSFLALSQLS PFLENFQSRF
NKKRKGLYRK AITEAAKAAK QLTPEVRALL TQFET
//
