ID G3QGI8_GORGO Unreviewed; 144 AA.
AC G3QGI8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Interleukin-33 {ECO:0000256|ARBA:ARBA00016804};
GN Name=IL33 {ECO:0000313|Ensembl:ENSGGOP00000001446.3};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000001446.3, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000001446.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000001446.3, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000001446.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000256|ARBA:ARBA00004398}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the IL-1 family. Highly divergent.
CC {ECO:0000256|ARBA:ARBA00007933}.
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DR EMBL; CABD030063917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004047836.1; XM_004047788.2.
DR AlphaFoldDB; G3QGI8; -.
DR Ensembl; ENSGGOT00000001473.3; ENSGGOP00000001446.3; ENSGGOG00000001464.3.
DR eggNOG; ENOG502RW83; Eukaryota.
DR GeneTree; ENSGT00390000005185; -.
DR HOGENOM; CLU_092450_0_0_1; -.
DR OrthoDB; 4642349at2759; -.
DR TreeFam; TF338120; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000001464; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR026145; IL-33.
DR PANTHER; PTHR21114; DVS27 PROTEIN; 1.
DR PANTHER; PTHR21114:SF0; INTERLEUKIN-33; 1.
DR Pfam; PF15095; IL33; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
SQ SEQUENCE 144 AA; 16223 MW; 99E2FA097F3F1148 CRC64;
MKPKMKYSTN KISTAKWKNT ASKALCFKLG NKVLLSYYES QHPSSESGDG VDGKMLMVTL
SPTKDFWLHA NNKEHSVELH KCEKPLPDQA FFVLHNMHSN CVSFECKTDP GVFIGVKDNH
LALIKVDSSE NLCTENILFK LSET
//
